AB - The Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence . , Sjwall C
, Chan KL
HRQoL: Health-related Quality of Life; ICAM: intercellular adhesion molecule; VCAM: vascular cell adhesion molecule; MCP-1: monocyte chemoattractant protein-1; NC: non-calcified; suPAR: soluble urokinase plasminogen activator receptor; LFA-REAL: Lupus Foundation of America Rapid Evaluation of Activity in Lupus; CES-D: Centers for Epidemiological StudiesDepression scale; SLAQ: Systemic Lupus Erythematosus Activity Questionnaire; NA: not acquired; NS: not significant. Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. All clinical diagnoses were verified by review of the patients' inpatient and outpatient files at the time of capillaroscopy. Use of Physician Global Assessment in systemic lupus - PubMed et al. BICLA is a validated composite global measure of SLE disease activity including SLEDAI-2K, CLASI-A, OCS dosage reduction, and patient-reported outcomes. Assessing disease activity in rheumatic diseases such as systemic lupus erythematosus (SLE) is vital for effective treatment. Results. This suggests that the role of the PGA is limited for disease activity assessment when used as a single instrument. Clipboard, Search History, and several other advanced features are temporarily unavailable. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of multifactorial origin that can affect any organ or organ system, resulting in a broad spectrum of clinical manifestations ranging from dermatological involvement to multi-organ failure with episodes of relapses and remissions. , Jnsen A
An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. et al. Use of Physician Global Assessment (PGA) in Systemic lupus Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. Objective: The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. , Schur PH. The assessment of PGA responsiveness was performed in 10 studies [4, 23, 50, 58, 7779, 81, 83, 84] using different methods [110]. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. Additional papers were obtained by checking the references from the selected studies. lupus erythematosus; systemic outcome assessment; qualitative research; healthcare; We read with great interest the recent paper by Aranow et al 1 about the impact of laboratory results on scoring of the Physician Global Assessment (PGA) of disease activity in systemic lupus erythematosus (SLE). A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). et al. COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items . T1 - Associations between physicians' global assessment of disease activity and patient-reported outcomes in patients with systemic lupus erythematosus. physician global assessment Recently Published Documents. Epub 2014 Apr 11. Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. Some may be a consequence of therapy and others may be . It was published in 1977 and was initially designed for the measurement of self-assessed pain in rheumatoid arthritis although it has since been used to evaluate RA more globally. 1 2. Schneider M
Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. 2014 - 20184 years. Global Automatic Chemiluminescence Immunoassay Analyzer Market 2023 , Suriano A
Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. The SELENA-SLEDAI assesses systemic lupus erythematosus (SLE) disease activity and categorizes mild/moderate or severe flares based on changes in the SLEDAI score, the Physician's Global Assessment (PGA), medication use (prednisone, Nonsteroidal anti-inflammatory drugs, Plaquenil, major immunosuppressives), other disease activity criteria, and . Physician global assessments for disease activity in rheumatoid Schlencker A, Messer L, Ardizzone M, Blaison G, Hinschberger O, Dahan E, Sordet C, Walther J, Dory A, Gonzalez M, Kleinlogel S, Bramont-Nachman A, Barrand L, Payen-Revol I, Sibilia J, Martin T, Arnaud L. Lupus Sci Med. , Ibanez D
Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. The responsiveness of the PGA was assessed through different methods [109, 113] showing a high sensitivity for detecting clinical variations [84]. Navarra SV
Karol DE
A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. , Gladman DD. Oxford Textbook of. Derivatives RWA Production Controller (SA-CCR/SLE) Nevertheless, despite the fact that the PGA was considered the reference in 39 studies involving other indices, it was used as the sole instrument in only 2 of them. This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. Myelogram - correct answer NPO for 4-6 hours. Arthritis Res Ther. et al. Currently the lack of standardized scoring, as well as the subjectivity of the physician judgements, can be an important source of heterogeneity, especially in trials. , Petri MA
AU - Morand, Eric. Liang et al. , Kostopoulou M
Content validity pertains to the degree to which the instrument measures all facets of a construct of interest [20]: this property is satisfied if the PGA is considered able to measure all aspects of disease activity in SLE in a comprehensive way. PDF Physician Global Assessment International Standardisation COnsensus in sharing sensitive information, make sure youre on a federal The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. At a glance: Common scores used in rheumatology The Physician Global Assessment (PGA) has been shown to be a valid, responsive, and feasible instrument to capture disease activity in systemic lupus erythematosus (SLE), but its low reliability further supports the need for a standardisation of its scoring. Your recommendations as to what might or should be done in relation to various issues observed. The OMERACT defines an instrument as an outcome measure if it passes the three pillars of evidence: truth (that refers to validity), discrimination (that includes reliability and responsiveness) and feasibility. Careers. This enabled the PGA to be considered the gold standard in several studies [2, 10, 11, 21, 23, 49, 67, 76, 78, 84, 88]. It does not provide a predefined or limited list of disease manifestations or organ systems, thus allowing one to capture all the heterogeneous aspects of SLE disease activity. ATI Comprehensive Predictor Exam 2019 (180 Q & A, Verified and 100 Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . , Dyer JW
[9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. It estimates how similar a given patients scores were at the two visits. , Bertsias G
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It operates in Albuquerque, and New Mexico. AU - Kandane-Rathnayake, Rangi. RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) , Jolly M. Mok CC
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ECG - correct answer no sleep the night before, meals allowed, no stimulants/tranquilizers for 24-48 hours before. Petri M
215 (FIVE YEARS 146) H-INDEX. Ensure second line of defense Derivatives RWA reviews are performed consistently and . , Sjwall C. Strand V
Meta-analysis of the studies reporting data concerning the construct validity between the PGA and SLEDAI. Measuring disease activity in adults with systemic lupus erythematosus An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . , Lau CS
X 20 Physician Global Assessment 10.1136/lupus-2019-lsm.176 . This property is reported across all articles selected through this systematic review [24, 913, 21103]. Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. et al. , Matos A
, Petri MA
Disclaimer. , Aggarwal R
The search strategy for SSc-related publications identified 75 citations . At least 1 issue from each virtual tour. , Farewell V
[8] suggested that the PGA should account for objective examination, laboratory results and what patients report. The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). , Sato JO
A good responsiveness for PGA was shown in eight studies. PGA is an important tool for assessing disease activity, response to treatment (it is a component . Keywords: Using the Physician Global Assessment in a clinical setting to - PubMed The following search strategy was used through MEDLINE via PubMed: (((lupus erythematosus, systemic[MeSH Terms] OR (lupus[TIAB] AND erythematosus[TIAB] AND systemic[TIAB]) OR systemic lupus erythematosus[TIAB] OR (systemic[TIAB] AND lupus[TIAB] AND erythematosus[TIAB]))) OR SLE[TIAB]) AND (physician global assessment[TIAB] OR PGA[TIAB]). , Sayedbonakdar Z
Thanks to this feature, the PGA was included in composite indices with the aim of rating manifestations not included in glossary-based instruments such as the SLEDAI and BILAG [3] or for which a threshold has been defined (cytopenia). Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. A new tool -- the Lupus Activity Scoring Tool (LAST) - has been proposed to join the ranks of current disease activity indices. Criterion validity data reporting correlation coefficients between PGA and quality of life measures, laboratory markers and miscellaneous. Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. et al. For permissions, please email: journals.permissions@oup.com. BILAGAB . The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. Cloud, mobility, security, and more. , Wallace DJ
A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [17], searching for articles reporting on the use of PGA in SLE. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. , Gladman DD
Several definitions of minimum clinically important difference were retrieved: in the SRI-4, a significant worsening was defined as an increase of >10% on the PGA-VAS [111], corresponding to 0.3 points from baseline; Touma et al. , Petri M. Thanou A
Unable to load your collection due to an error, Unable to load your delegates due to an error. Laboratory Investigation Results Influence Physician's Global An acceptable reliability is indicated by values of intraclass correlation coefficient (ICC) or weighted >0.60 and a good reliability is >0.85 [20]. , Altman DG
Medizinische Universitt Graz Austria/sterreich - Forschungsportal et al. In this sense, criterion validity of PGA is satisfied when scores correlate with phenomena subsequently influenced by disease activity, such as quality of life measurements (Health-related Quality of Life, 36-item Short Form Health Survey, Functional Assessment of Chronic Illness TherapyFatigue score, Lupus Impact Tracker and LupusPRO), biomarker levels (complement fractions, ESR, autoantibodies), treatment variations and damage assessments (SDI).