2009 Jan;70(1):116-23. doi: 10.1111/j.1365-2265.2008.03327.x.Am J Med. 2020 Mar;9(Suppl 2):S160-S170. Epub 2005 Apr 23.Dougherty RH, Rohrer JL, Hayden D, Rubin SD, Leder BZ.Clin Endocrinol (Oxf). Serum HDL levels decreased significantly, but clinically irrelevantly in one trial (−0.1 mmol/L in 6 months), but serum LDL levels increased markedly in another (+14%).Six RCTs assessing the use of SERMs for functional hypogonadism were included with a total of 476 participants (Table The patients were treated with clomiphene citrate (25 or 50 mg) or enclomiphene citrate (6.25, 12.5, or 25 mg). Unable to load your delegates due to an error 2020 May 15;11:277. doi: 10.3389/fendo.2020.00277. Only the inclusion criteria of Soares et al fulfilled all of the criteria for the diagnosis of functional hypogonadism according to the Endocrine Society guideline.Treatment with SERMs was able to increase total T levels equally high as transdermal T gel. Name must be less than 100 characters Only articles published in English were included.
When sexual function or anemia was investigated, the presence of symptoms was not required for inclusion. Sexual symptoms include erectile dysfunction, reduced frequency of sexual thoughts, and weakened morning erections.T is however not the only important sex steroid hormone mediating these functions in men. Following aromatase inhibition, only minimal improvement of body composition and physical function was observed in some of the trials, but spinal BMD decreased. 23 Analysis of data from 14 patients revealed no objective responses and minimal evidence of pain relief. Silverchair Information Systems 2001 May;110(7):563-72. doi: 10.1016/s0002-9343(01)00663-5.J Am Geriatr Soc. We investigated the ability of the orally administered aromatase inhibitor, anastrozole, to increase endogenous testosterone production in 37 elderly men (aged 62-74 yr) with screening serum testosterone levels less than 350 ng/dl. Moreover, supraphysiological total T levels are not reached. None of the inclusion criteria completely matched the guidelines of the Endocrine Society with respect to the diagnosis of functional hypogonadism. The data showing increased aromatase expression in leiomyomas led us to evaluate the aromatase expression in the histologic adenomyoma specimens from this patient. 2019 May 1;129(5):1818-1826. doi: 10.1172/JCI125755. In 2018, the European Medicines Agency (EMA) did not approve a marketing authorization for enclomiphene (brand name EnCyzix/Androxal—Renable pharma (UK)/Repros therapeutics (US)) for treatment of functional hypogonadism in overweight and obese men.Most of the included RCTs enrolled only a small number of men and had a short follow‐up period. Inclusion criteria were heterogenic. Furthermore, none of the included studies demonstrated an effect on Hb1Ac, possibly because of their limited duration.
The physiological consequences of these changes remain to be determined.
Furthermore, the induced decrease in EIn contrast, SERMs might be a more promising alternative for TRT, but until now, RCTs have mainly focused on their ability to raise total T levels and their effect on semen parameters. One study even reported an increase in sperm count.Only limited information on physical function was gathered through the (q)ADAM questionnaire.
One RCT compared AIs versus SERMs in 24 men. Sixteen males were supplemented with either 300 mg or 600 mg of 6-OXO in a double-blind manner for eight weeks. Normal feedback is indicated in blue, effects of AIs are indicated in green, and effects of SERMs are indicated in red Another advantage of SERMs in contrast with TRT is the preservation of fertility, as they have a neutral effect on semen parameters.
A small decrease in BMI and waist circumference was seen in men with IGT.There is no conclusive evidence for an improvement in glucose homeostasis after SERM treatment.
Knowledge about long‐term cardiovascular, thrombo‐embolic, and prostatic risks is lacking.
Importantly, the oral administration can contribute to a better therapy compliance and local adverse effects caused by transdermal TRT are avoided.
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