Observing aromatase inhibitors patients at high risk of fracture, bisphosphonate‐treated patients had an HR 0.73 [95% CI, 0.51 to 1.04] and SHR 0.69 [95% CI, 0.48 to 0.98] compared to nontreated. 2019 Jan 18;17(1):17. doi: 10.1186/s12955-019-1090-4.Dionísio MR, Mansinho A, Abreu C, Cavaco-Silva J, Casimiro S, Costa L.Br J Clin Pharmacol. Epub 2010 Nov 3.Tenti S, Correale P, Cheleschi S, Fioravanti A, Pirtoli L.Int J Mol Sci. 2012 Feb;12(1):40-8. doi: 10.1016/j.clbc.2011.08.002. Hadji P, Body JJ, Aapro MS, Brufsky A, Coleman RE, Guise T, Lipton A, Tubiana-Hulin M.Ann Oncol. Epub 2019 Feb 16. To evaluate bone status and predict risk for fractures, lateral thoracic and lumbar spine X-ray imaging, bone mineral density measurement by dual energy X-ray absorptiometry at the lumbar spine L1–L4 vertebrae and/or hip and fracture risk factors assessment are mandatory tests prior to hormonal treatment. These are compelling reasons to ensure that all women on AI therapy for breast cancer receive early assessment and treatment.”Among its conclusions, the position statement states:Professor Peyman Hadji, first author of the paper and board member of the Cancer and Bone Society, added:As fragility fractures often result in prolonged disability and loss of independence, it is important that women who are being treated for hormone-sensitive breast cancer are managed to prevent bone loss and related fractures. doi: 10.3390/ijms21165625.Gralow JR, Barlow WE, Paterson AHG, M'iao JL, Lew DL, Stopeck AT, Hayes DF, Hershman DL, Schubert MM, Clemons M, Van Poznak CH, Dees EC, Ingle JN, Falkson CI, Elias AD, Messino MJ, Margolis JH, Dakhil SR, Chew HK, Dammann KZ, Abrams JS, Livingston RB, Hortobagyi GN.J Natl Cancer Inst. 2019 Apr 2;14(4):e0214153. Bone demineralization and aromatase inhibitors. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Unable to load your delegates due to an error 2012 Feb;12(1):40-8. doi: 10.1016/j.clbc.2011.08.002. Aromatase inhibitors: Block conversion of androgens into estrogen → Low estradiol → enhanced bone loss → high fracture risk. Epub 2012 Jan 20.Llombart A, Frassoldati A, Paija O, Sleeboom HP, Jerusalem G, Mebis J, Deleu I, Miller J, Schenk N, Neven P.Clin Breast Cancer. Epub 2008 Apr 29.Hadji P, Aapro MS, Body JJ, Gnant M, Brandi ML, Reginster JY, Zillikens MC, Glüer CC, de Villiers T, Baber R, Roodman GD, Cooper C, Langdahl B, Palacios S, Kanis J, Al-Daghri N, Nogues X, Eriksen EF, Kurth A, Rizzoli R, Coleman RE.J Bone Oncol. Practical guidance for the management of aromatase inhibitor … Aromatase inhibitors (AIs) are an important component of adjuvant endocrine therapy in postmenopausal women with estrogen receptor (ER)-positive breast cancer. Production and hosting by Elsevier B.V.ScienceDirect ® is a registered trademark of Elsevier B.V.
2017 Mar 23;7:1-12. doi: 10.1016/j.jbo.2017.03.001. Side effects of aromatase inhibitors. Morbidity and mortality associated with bone loss can be prevented with appropriate screening, lifestyle interventions, and therapy. Clipboard, Search History, and several other advanced features are temporarily unavailable. doi: 10.1371/journal.pone.0214153.
Aromatase inhibitors (AIs) are an important component of adjuvant endocrine therapy in postmenopausal women with estrogen receptor (ER)-positive breast cancer. Numerous reports have demonstrated that aromatase suppression leads to clinically significant bone demineralization resulting in increased rates of osteopenia, osteoporosis, and fractures (Table (Table1). The aromatase inhibitors (AIs) anastrozole (Arimidex), letrozole (Femara), and exemestane (Aromasin) are significantly more effective than the selective estrogen-receptor modulator (SERM) tamoxifen in preventing recurrence in estrogen receptor-positive early breast cancer. 2019 Jun;85(6):1114-1124. doi: 10.1111/bcp.13852. Need baseline and follow up BMD testing. 2010;79(1-2):13-26. doi: 10.1159/000314997. The treatments are generally well-tolerated but by dramatically reducing oestrogen levels, aromatase inhibitors can increase the rate of bone loss and the risk of fractures. Unable to load your collection due to an error Elsevier Science Elsevier Science COVID-19 is an emerging, rapidly evolving situation. Most breast cancers are diagnosed at an early stage, when all detected deposits of the disease are in the breast or nearby lymph nodes and can be removed surgically.
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