Tests look for changes or variations in these genes that determine whether a medication could be an effective treatment for you or whether you could have side effects from a specific medication.The cytochrome P450 enzyme includes the CYP2D6 enzyme, which processes many antidepressants and antipsychotic medications. The EGAPP™ Working Group examined the scientific evidence to see whether CYP450 genetic testing is … The FDA classifies genetic tests as medical devices, and they are subject to FDA regulation.
For example, results of a CYP2D6 test may show which of these four types applies to you:CYP450 testing isn't useful for all antidepressants, but it can provide information about how you're likely to process a number of them.
Cytochrome 450 2D6 Genotype detects eight alleles associated with the poor metabolizer phenotype (PM). PMs have reduced enzyme activity and may require alternative therapeutic treatment or adjustment of standard dosage regime to reduce the risk of concentration-dependent side effects, overdose drug toxicity or prolonged therapeutic effect as a result of impaired clearance of drug. CYP3A5: *3,*6,*7) in PCR-multiplex format. This test is not indicated to be used to predict drug response or non-response. Only alleles listed will be identified by this product. It is important to interpret genotyping test results in the context of an individual's profile.This assay utilizes the Luminex xTAG® CYP2C19 Kit v3 US-IVD.The xTAG® CYP2C19 Kit v3 is an in vitro diagnostic test used to simultaneously detect and identfy a panel of nucleotide varients found within the highly polymorphic CYP450 2C19 gene, located on chromosome 10q24, from genomic DNA extracted from EDTA or citrate anticoagulated whole blood samples. The xTAG® CYP2C19 Kit v3 incorporates multiplex Polymerase Chain Reaction (PCR) and multiplex Allele Specific Primer Extension (ASPE) with a proprietary universal array system on the Luminex platform.Drug-metabolizing phenotypes can be classified according to the level of metabolism: poor metabolizers (PMs), intermediate metabolizers (IMs), extensive metabolizers (EMs), and ultra-rapid metabolizers (UMs). Maintain specimen at room temperature or refrigerate at 4°C.Frozen specimen; hemolysis; quantity not sufficient for analysis; improper containerThe xTAG® CYP2C19 Kit v3 is a qualitative genotyping assay, which can be used as an aid to clinicians in determining therapeutic strategy for the therapeutics that are metabolized by the CYP2C19 gene product.
Testing schedules may vary. The *17 allele is the only UM allele identified thus far for CYP2C19.
Because of inherited (genetic) traits that cause variations in these enzymes, medications may affect each person differently.Drug-gene testing — also called pharmacogenomics or pharmacogenetics — is the study of how genes affect your body's response to medication. The xTAG® CYP2C19 Kit v3 is an in vitro diagnostic test used to simultaneously detect and identfy a panel of nucleotide varients found within the highly polymorphic CYP450 2C19 gene, located on chromosome 10q24, from genomic DNA extracted from EDTA or citrate anticoagulated whole blood samples. The Roche AmpliChip CYP450 Test identifies drugs metabolized through the CYP2D6 and CYP2C19 enzyme systems. The consequence of a *17 allele with a loss of function allele may be in between the EM and IM phenotypes and may possibly be substrate dependent.Variations in CYP2C19 enzyme activity can lead to a variety of clinical implications. Join Date: Nov 2006; Posts: 10778; Share Tweet #5. EMs who are heterozygous for a varient allele with a non-functional allele may have a modest decrease in enzyme activity. LabCorp's test menu provides a comprehensive list of specialty and general laboratory testing services. Featured Test: Genetic Testing.
Cytochrome P450 enzymes can be inhibited or induced by drugs, resulting in clinically significant drug-d… johnep. Cytochrome P450 3A4/5 (CYP3A4/3A5) acts on approximately half of all drugs in clinical use. Depending on the combination of alleles in an individual, drug-metabolizing phenotypes associated with the CYP2C19 enzyme can vary.The kit is not indicated for stand-alone diagnostic purposes. Many alleles of CYP2C19 encode enzymes that have non-functional, decreased or increased enzyme activity compared to wild-type.
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