Cyclophosphamide should not be administered to patients with neutrophils ≤1,500/mmHemorrhagic cystitis, pyelitis, ureteritis, and hematuria have been reported with Cyclophosphamide. Prolonged apnea may occur with concurrent depolarizing muscle relaxants (e.g., succinylcholine). Discontinue Cyclophosphamide therapy in case of severe hemorrhagic cystitis.Urotoxicity (bladder ulceration, necrosis, fibrosis, contracture and secondary cancer) may require interruption of Cyclophosphamide treatment or cystectomy. Discontinue cyclophosphamide therapy in case of severe hemorrhagic cystitis. The elimination half-life (tCyclophosphamide administered by different routes, including intravenous, subcutaneous or intraperitoneal injection, or in drinking water, caused tumors in both mice and rats. Because they are reported from a population from unknown size, precise estimates of frequency cannot be made.Cyclophosphamide is a pro-drug that is activated by cytochrome P450s An increase of the concentration of cytotoxic metabolites may occur with:Combined or sequential use of Cyclophosphamide and other agents with similar toxicities can potentiate toxicities.Etanercept: In patients with Wegener’s granulomatosis, the addition of etanercept to standard treatment, including Cyclophosphamide, was associated with a higher incidence of non-cutaneous malignant solid tumors.Metronidazole: Acute encephalopathy has been reported in a patient receiving Cyclophosphamide and metronidazole.
Affected patients generally resume regular menses within a few months after cessation of therapy. … Available for Android and iOS devices. Cyclophosphamide appears to induce its own metabolism. Neutropenia, thrombocytopenia, low hemoglobin, and diarrhea have been reported in infants breast fed by women treated with cyclophosphamide. Advise females of reproductive potential to use effective contraception during treatment with Cyclophosphamide Injection and for up to 1 year after completion of therapy Based on findings in genetic toxicity and animal reproduction studies, advise male patients with female partners of reproductive potential to use effective contraception during treatment with Cyclophosphamide Injection and for 4 months after completion of therapy Amenorrhea, transient or permanent, associated with decreased estrogen and increased gonadotropin secretion develops in a proportion of women treated with cyclophosphamide. Although it has some tumour selectivity, it also possesses a wide spectrum of toxicities. Most advocate daily oral cyclophosphamide regimens, but intermittent pulse cyclophosphamide may be substituted to reduce the toxicity of extended therapy. Cyclophosphamide interferes with oogenesis and spermatogenesis. In this study there was no evidence of a blunting of the antihypertensive … Select one or more newsletters to continue. Cyclophosphamide is activated to form 4-hydroxycyclophosphamide, which is in equilibrium with its ring-open tautomer aldophosphamide. Medical and/or surgical supportive treatment may be required to treat protracted cases of severe hemorrhagic cystitis. Cyclophosphamide is teratogenic and embryo-fetal toxic in mice, rats, rabbits and monkeys.Advise pregnant women and females of reproductive potential of the potential risk to the fetus Verify the pregnancy status of females of reproductive potential prior to initiation of Cyclophosphamide Tablets. Advise patients on the potential risks for infertility Cyclophosphamide may interfere with normal wound healing.Hyponatremia associated with increased total body water, acute water intoxication, and a syndrome resembling SIADH (syndrome of inappropriate secretion of antidiuretic hormone), which may be fatal, has been reported.The following adverse reactions are discussed in more detail in other sections of the labeling.The following adverse reactions have been identified from clinical trials or post-marketing surveillance. Some metabolites are protein bound to an extent greater than 60%. This may result in increased toxicity Cyclophosphamide and its metabolites are dialyzable although there are probably quantitative differences depending upon the dialysis system being used. There are isolated reports of hemorrhagic colitis, oral mucosal ulceration and jaundice occurring during therapy.Alopecia occurs in patients treated with cyclophosphamide. Therefore,Cyclophosphamide Tablets should be taken in the morning.Cyclophosphamide Tablets should be swallowed whole. Some degree of testicular atrophy may occur. Inactive ingredients in Cyclophosphamide Tablets are: acacia, FD&C Blue No. Cyclophosphamide-induced sterility may be irreversible in some patients.
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