LiverTox® provides up-to-date, unbiased and easily accessed information on the diagnosis, cause, frequency, clinical patterns and management of liver injury attributable to prescription and nonprescription medications and selected herbal and dietary supplements. Palbociclib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).PAZOPanib: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of PAZOPanib. taken, how much, and when it happened. When used in combination with other agents (eg, ribavirin), the contraindications to those agents also apply (refer to respective labeling information).Treatment-naive without cirrhosis (alternative agent): 60 mg once daily with concomitant sofosbuvir for 12 weeks (AASLD/IDSA 2018).Peginterferon/ribavirin-experienced patients without cirrhosis (alternative agent): 60 mg once daily with concomitant sofosbuvir for 12 weeks (AASLD/IDSA 2018).Patients with decompensated (Child-Pugh class B or C) cirrhosis: 60 mg once daily with concomitant sofosbuvir and ribavirin for 12 weeks. Monitor HCV/HBV coinfected patients for hepatitis flare or HBV reactivation during HCV treatment and post-treatment follow-up. Colchicine distribution into certain tissues (e.g., brain) may also be increased. However, many people have no side effects or only have minor side effects. If you have questions about side effects, call your doctor. Management: If combined, administer the P-gp inhibitor simultaneously with, or after, the dose of afatinib. He experienced severe nausea and constant retching, which was not controlled by metoclopramide and ribavirin was stopped.
Read all information given to you. When HCV infection is detected during pregnancy, treatment should be deferred until after delivery. Follow all instructions closely.
Management: Avoid concomitant use of lefamulin tablets with P-glycoprotein/ABCB1 inhibitors.
Powerful learning and clinical decision support tools combined into one platform. It is reasonable to continue regimen in the perioperative period . Some cases have resulted in fulminant hepatitis, hepatic failure, and death. Optimal duration of treatment for HCV genotype 3-infected patients with cirrhosis or HCV genotype 1 patients with Child-Pugh class C cirrhosis has not been established.• Appropriate use: Do not use as monotherapy; use only in combination with other antihepatitis C virus drugs.Baseline (within 12 weeks prior to treatment initiation) CBC, INR, hepatic function (albumin, total and direct bilirubin, ALT, AST, alkaline phosphatase), calculated GFR; baseline (obtain any time prior to treatment initiation) HCV genotype and subtype, quantitative HCV viral load. If coadministration cannot be avoided, closely monitor for increased alpelisib adverse reactions.Amiodarone: Daclatasvir may enhance the bradycardic effect of Amiodarone.
Search by Interacting Drug . Anti-emetics . If concomitant use is required, monitor for lefamulin adverse effects.MiFEPRIStone: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors). Sarilumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).Silodosin: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Silodosin. Ranolazine: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Ranolazine.
Antidiabetic Agents: Direct Acting Antiviral Agents (HCV) may enhance the hypoglycemic effect of Antidiabetic Agents. Daclatasvir is a first-in-class HCV NS5A replication complex inhibitor, and sofosbuvir is a nucleotide analogue HCV NS5B polymerase inhibitor. Call your doctor for medical Management: Decrease the daclatasvir dose to 30 mg once daily if combined with a strong CYP3A4 inhibitor.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Canadian labeling states that the combination of daclatasvir and rifapentine is contraindicated.RifAXIMin: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of RifAXIMin.
More than 250 of the most commonly prescribed medications are impacted by individual genetic factors, that the FDA has included information and warnings around genetic variations and the importance of DNA drug sensitivity testing in the drug packaging and on labels. Available for Android and iOS devices. For patients with genotype 1 HCV, the regimen of daclatasvir with peginterferon and ribavirin was only moderately effective.
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