Safe conditions for use of Doxepin Hydrochloride Cream, 5% in children have not been established. This medication is for use on the Do not cover the area with plastic or waterproof bandages.
Each gram contains: 50 mg of doxepin hydrochloride (equivalent to 44.3 mg of doxepin). Do not cover treated skin area with a bandage or plastic. The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide). Doxepin hydrochloride has a molecular formula of C19H21N…
It is possible that doxepin may also be excreted in human milk following topical application of Doxepin Hydrochloride Cream, 5%.One case has been reported of apnea and drowsiness in a nursing infant whose mother was taking an oral dosage form of doxepin HCl.Because of the potential for serious adverse reactions in nursing infants from doxepin, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.The use of Doxepin Hydrochloride Cream, 5% in pediatric patients is not recommended. Covering the treated area may increase the absorption of the medication through the Do not use more of this product, use it more often, or keep using it longer than prescribed by your doctor. However, the efficacy with reduced frequency of applications has not been established.Sedating drugs may cause confusion and oversedation in the elderly; elderly patients generally should be observed closely for confusion and oversedation when started on Doxepin Hydrochloride Cream, 5%.
Wash hands immediately after use unless the area being treated includes the hands.
Desmethyldoxepin has a half-life that ranges from 28 to 52 hours and is not affected by multiple dosing. Tell all your doctors you use this medication.If you miss a dose, apply it as soon as you remember. Of particular importance, sufficient time must elapse before initiating TCA treatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary).Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Each gram contains: 50 mg of doxepin hydrochloride (equivalent to 44.3 mg of doxepin). A total of 27 grams had been applied over three days for eczema. (See Studies have not been performed examining drug interactions with Doxepin Hydrochloride Cream, 5%. The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. Each gram contains: 50 mg of doxepin hydrochloride (equivalent to 44.3 mg of doxepin).
Keep all Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Systemic Adverse Effects: In controlled clinical trials of patients treated with Doxepin HCl Cream 5%, the most common systemic adverse effect reported was drowsiness.
It is desirable to monitor TCA plasma levels whenever a TCA is going to be co-administered with another drug known to be an inhibitor of P450 2D6.Carcinogenesis, mutagenesis, and impairment of fertility studies have not been conducted with doxepin hydrochloride.Pregnancy: Reproduction studies have been performed in which doxepin was orally administered to rats and rabbits at doses up to 0.6 and 1.2 times, respectively, the estimated exposure to doxepin that results from use of 16 grams of Doxepin Hydrochloride Cream, 5% per day (four applications of four grams of cream per day; dose multiples reflect comparisons made following normalization of the data on the basis of body surface area estimates) and have revealed no evidence of harm to rat or rabbit fetuses due to doxepin.
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