The pharmacokinetics of metaxalone have been evaluated in healthy adult volunteers after single dose administration of metaxalone tablets under fasted and fed conditions at doses ranging from 400 mg to 800 mg. Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system (CNS).
The use of alcohol or other medicines that affect the CNS with metaxalone may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping.
There needs to be chloroquine phosphate tablets buy less testing throughout the year, but. Metaxalone Tablets are available as an 800mg oval, convex, pink tablet with one side debossed “M” and the other side and scored on the other side debossed "58/59".Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].This Product was Repackaged By Sandhills Packaging for:Table 1: Mean (%CV) Metaxalone Pharmacokinetic ParametersFigure 1. The recommended dose for adults and children over 12 years of age is one 800 mg tablet three to four times a day. Taking metaxalone tablets with food may enhance general CNS depression; elderly patients may be especially susceptible to this CNS effect. Therefore, caution should be exercised with patients who take more than one of these CNS depressants simultaneously.
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Therefore, metaxalone tablets should not be used in women who are or may become pregnant and particularly during early pregnancy unless, in the judgement of the physician, the potential benefits outweigh the possible hazards.It is not known whether this drug is secreted in human milk. Reproduction studies in rats have not revealed evidence of impaired fertility or harm to the fetus due to metaxalone. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle.
Generic cialis oral jelly bactrim or cipro for kidney infection much does azulfidine cost single dose tinidazole giardiasis. Thereafter, metaxalone concentrations decline log-linearly with a terminal half-life of 9.0 ± 4.8 hours. Safety and effectiveness in children 12 years of age and below have not been established.The most frequent reactions to metaxalone include: Though rare, anaphylactoid reactions have been reported with metaxalone.Deaths by deliberate or accidental overdose have occurred with metaxalone, particularly in combination with antidepressants and have been reported with this class of drug in combination with alcohol.
Known tendency to drug induced, hemolytic or other anemias. The effect of gender on the pharmacokinetics of metaxalone was assessed in an open label study, in which 48 healthy adult volunteers (24 males, 24 females) were administered two metaxalone 400 mg tablets (800 mg) under fasted conditions.
Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, other muscle relaxants, or anesthetics, including some dental anesthetics. Metaxalone should be administered with great care to patients with pre-existing liver damage. Safe use of metaxalone has not been established with regard to possible adverse effects upon fetal development. (See Metaxalone tablets may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle, especially when used with alcohol or other CNS depressants. These are not all the possible side effects of Skelaxin.
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