The hardness of WG tablets was highly sensitive to moisture content both during compression and subsequent storage, and, although not to the same extent, the hardness of SG tablets was also affected by loss-on-drying levels. Ketoconazole solution was prepared by dissolving ketoconazole powder in polyethylene glycol 400 and stored at room temperature. soluble in water, slightly soluble in ethanol (96%), and practically insoluble in chloroform and in ether.
Quality control tests, 1 0 obj The pK, of metformin is 12.4. Thus, we synthesized ten new pharmaceutical salts ( Fig. Ergosterol is a phytosterol consisting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group. 11, respectively. <> B. Ultraviolet and visible absorption spectrophotometry (2.2.25). ?��.���|�v��һN��]~ ���y `��d�T���4��:߭6f����D4&=�JP����A�ͮ���ߗn~]�|An��������~�@u}�ag�JʔfG ��5]_�����M����ǁ�`Du�y:��]A$�/q�[ �k���6�O��@kP#jҠ�ƕ�q�#I�ޣ�9@HϬؠ���!9�C�F.j�6 /����:xE R�Б�K�� It is a 3beta-sterol, an ergostanoid and a member of phytosterols. 4 0 obj J Pharm 348 Sci.
MG provided a robust manufacturing process with highest compactibility and lowest friability that were not sensitive to changes in atmospheric moisture level. 3 0 obj<>stream Ver.
2 0 obj<>/ColorSpace<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]/ExtGState<>>> endobj achieve the SR pattern if the solubility of metformin was decreased. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether and chloroform. Metformin - Ingredients: Preserved Water (Parabens) ... plug ear with cotton for 15 - 30 minutes - Flush with luke walk water. p�$y�oHX~%/�h�PQ�kuPh���̼M��� ]�g�7��=kr��L�B�ʏ�6d|/ȸ�}����n�Y ����{�����=G��O�З�1�H��c����R�>� ���g�B�=�gC���B��o�x�h��r�eh�@�>E�(�%��y�oՆ~z/uƴ/�h�"�2�^T�k�Պe�Uzg��������:-�j�H~J�e��m�䫍wFo�<=�aq������0P{���-(��N&`g���n�,�Gm�E{�I���pD �T�e 0���?���k�U�x�M���� #j��1^"i���H&C�o��H�%�,����Eq�#�� W��$�wz�0[zg��%��chjH�O��̑ ��(!%�mG(96B��i�0I�hJ�X"X��_��*�+R^�ט���C�hq�o��I~�^7��bܞpr�qk�jX��L���� H��W�r#��#���c�=��ګ���-��-�x��I��B�h��~/� AZ���%+ח/_~��㯿~�������ի7���a�f:z9�ڱO�G]�a��tM��l}�u)���Q+{����?_���~�6m��t��������?>�&4��X��U��[=��mL��ן�{]������O��S����7M�"~`��3������R��zy�D<=}7��Mc-����K�K-����x\�����l�j����W��xv�_�wW�����X #��c�c�xb�֎w��z����|Od�fbn:��39�O���凵�ێ�^��:7>���3�\1��j��^�v���{�߉����A��/�*tP�[u��E�W��9�0D@�n�:�!�n��̗w���xh�=X�-��mz�T˚ނW���( �I���j���z�Y��}���fk�pd�e����M_�j!�L��xl�`��Ԍ�z��.����>�����?
© 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:1553-1565, 2011. *���ٗ-���L�5h��ԗ-��\����V/&Q2Y�� �V0o+��a�~5[�ra'�&�!ɱ���E'H2��X��ٍ�t�Q ��^�R����Ҍaf���b�_j��eZ��^��Z)@>�]���d��V�3�����[Xҟ/��H�S7��u��g�M����Z�H1�b�>T?㯁��,#�f��� �̪�B>��h��aR�VX*W��/Md2���Q.���]�.�d���4zWw ژ�e�T��k���.8ic.0����a�� An acidic salt of an organic amine. Sr. No. ?�1�Oo����Ͼ=�����b_{�^F���V�0����*�ޛ����3�k��,��ƪ'*iF{�~�!���W�;�F���Xx�y�>�z; ^��ev��J�,��&]{�8�������m��cr��$e�����O�$M��ɩ]�h��PԷ�c���]?X���bO�~ �4��s�����=��ntc�n (ed.). The adhesiveness of patch was good. pH of a 1% aqueous solution: 7.5-8.5 /21-Phosphate disodium salt/ O'Neil, M.J. water-soluble drug Ketoconazole. MG was compared with modified wet granulation (WG) and solvent granulation (SG) processes. Ingredients Qty. 1 0 obj<> endobj
Metformin hydrochloride is a white to off-white crystalline compound with a molecular formula of C 4 H 11 N 5-HCL and a molecular weight of 165.63 g/mol. endobj (mg) 1 Ketoconazole 100 2 Avicel pH-102 587.66 3 Aerosil-200 30.92 4 Sodium starch Glycollate 35.92 5 Magnesium Stearate 7.18 Total weight (mg) 761.1 TABLE 3 Formula for conventional wet2 300 GALVUMET tablets are available in 3 strengths: • 50 mg vildagliptin and 500 mg metformin hydrochloride: light yellow, ovaloid bevelled edge, film-coated tablet imprinted with … 2 0 obj �� rv�|ďi�� 346 4.
Unlike salts, the pH max of cocrystals of basic drugs and acidic coformers can occur on either side of the solubility minimum depending on pK sp and S 0,D. %���� Solubility: Freely soluble in methylene chloride soluble in methanol, sparingly soluble in ethanol,practically insoluble in water: Complies: 3: Identification: IR: The IR spectrum correspond to Ketoconazole reference standard: Complies: 4: Melting point (°C) Between 148 to 152: 148‐150: 5: <>/XObject<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>>
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