Based upon the known hemodynamic effects of dipyridamole, symptoms such as warm feeling, flushes, sweating, restlessness, feeling of weakness, and dizziness may occur. Each hard gelatin capsule contains 200 mg dipyridamole, USP in an extended-release form and 25 mg aspirin USP, as an immediate-release sugar-coated tablet. Patients should be observed for at least four hours after ingestion of potentially toxic amounts. • Indometacin may mask the signs and symptoms of infection, so antibiotic therapy should be initiated promptly if an infection occurs during therapy with indometacin. An increased risk of hyperkalaemia has also been reported when NSAIDs are taken with ACE inhibitors.
With intravenous (i.v.) • Pentoxifylline: possible increased risk of bleeding when taken with NSAIDs. Note: ER-DP = extended-release dipyridamole 200 mg; ASA = aspirin 25 mg. ESPS2 was a double-blind, placebo-controlled study that evaluated 6,602 patients over the age of 18 years who had a previous ischemic stroke or transient ischemic attack within ninety days prior to entry. Both values correspond well with data from the literature at lower doses which state a resultant half-life of approximately 2 to 3 hours. GI bleeding, ulceration or perforation, which can be fatal, has been reported with all NSAIDs at any time during treatment, with or without warning symptoms or previous history of serious GI events. In a study conducted with an intravenous formulation of dipyridamole, patients with mild to severe hepatic insufficiency showed no change in plasma concentrations of dipyridamole but showed an increase in the pharmacologically inactive monoglucuronide metabolite. “Who should not take aspirin and extended-release dipyridamole capsules?” aspirin and extended-release dipyridamole capsules? • During prolonged therapy, periodic ophthalmic examinations are recommended, as corneal deposits and retinal disturbances have been reported. Plasma electrolytes and pH should be monitored serially to promote alkaline diuresis of salicylate if renal function is normal.
A. D. Diamox … Counsel patients who consume three or more alcoholic drinks daily about the bleeding risks involved with chronic, heavy alcohol use while taking aspirin. Milk samples were collected at steady-state, at 0, 1, 2, 4, 8, 12, and 24 hours after taking a dose of aspirin. The incidence rate of all-cause mortality was 11.3% for aspirin and extended-release dipyridamole, 11.0% for aspirin alone, 11.4% for extended-release dipyridamole alone and 12.3% for placebo alone. Caution is advised with concomitant use of live vaccines. In the event of intolerable headaches during initial treatment, switch to one capsule at bedtime and low-dose aspirin in the morning. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate reliably their frequency or establish a causal relationship to drug exposure. Caution should be advised in patients receiving concomitant medications which could increase the risk of ulceration or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors or anti-platelet agents such as aspirin (see section 4.5).
Dipyridamole can be dosed without restriction as long as there is no evidence of hepatic failure. The dosage regimen for all treatment groups is BID. When increases in the dose of indometacin are made under these circumstances, they should be made cautiously and in small increments. Patients taking aspirin in combination with anagrelide are at an increased risk of bleeding. Aspirin and extended-release dipyridamole capsules are contraindicated in patients with known hypersensitivity to any of the product components. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X.If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. Patients received one capsule twice daily (morning and evening). • Corticosteroids: Increased risk of gastro-intestinal ulceration or bleeding (see section 4.4). If you are a consumer or patient please visit The concurrent use of aspirin with other NSAIDs may increase bleeding or lead to decreased renal function.Moderate doses of aspirin may increase the effectiveness of oral hypoglycemic drugs, leading to hypoglycemia. Consider gastric emptying and/or lavage as soon as possible after ingestion, even if the patient has vomited spontaneously.
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