Emons, G.; Mustea, A.; Tempfer, C. Tamoxifen and Endometrial Cancer: A Janus-Headed Drug. Endometrial adenocarcinomas associated with prolonged tamoxifen treatment have been attributed to a possible genotoxic effect of tamoxifen in the endometrium (9, 10), although the evidence for this is not considered convincing , because of the low level of DNA adducts that have been found in endometrial biopsies from women taking tamoxifen (9, 10). In addition, five women displayed evidence This site needs JavaScript to work properly. 2009 Jan;112(1):150-4. doi: 10.1016/j.ygyno.2008.08.035. As it has low toxicity and is widely available, tamoxifen has become one of the most frequently prescribed anticancer drugs worldwide. The statements, opinions and data contained in the journals are solely Epub 2008 Oct 19.Gynecol Oncol. Therefore, any patient who develops bleeding while taking tamoxifen requires evaluation. This article reviews the clinical data on these controversial effects of tamoxifen and the possible explanations. High-grade endometrial carcinoma in tamoxifen-treated breast cancer patients From this retrospective study, it appears that women receiving tamoxifen as treatment for breast cancer who subsequently develop uterine cancer are at risk for high-grade endometrial cancers that have a poor prognosis. We use cookies on our website to ensure you get the best experience.tamoxifen; endometrial cancer; selective estrogen receptor modulator Find support for a specific problem on the support section of our website. However, tamoxifen increases the risk of endometrial cancer (EC) by about 2–7 fold, and more aggressive types of EC with poor prognoses are observed in tamoxifen users.
Multiple requests from the same IP address are counted as one view. A major side effect of tamoxifen is to increase the risk of uterine corpus cancer (endometrial cancer). See further details All the women were menopausal and had vaginal bleeding. Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. Tamoxifen is a selective estrogen receptor modulator used for the treatment and prevention of estrogen receptor (ER)—positive breast cancer. "Tamoxifen and Endometrial Cancer: A Janus-Headed Drug." Help us to further improve by taking part in this short 5 minute survey 2014 Jun 10;110(12):2874-80. doi: 10.1038/bjc.2014.263. We investigated whether tamoxifen therapy increases mortality among breast cancer patients subsequently diagnosed with endometrial cancer. 2020. Up to one-half of breast cancerpatients who are treated with tamoxifen may develop an endometrial lesion within 6-36 months. Tamoxifen is a selective estrogen receptor modulator used for the treatment and prevention of estrogen receptor (ER)—positive breast cancer. On the other hand, tamoxifen is an efficacious treatment for certain forms of advanced endometrial cancer, thus making it a Janus-headed drug that can support the development of endometrial cancer on one hand and be used as a remedy for this disease on the other. Epub 2014 Sep 12.Nagy E, Gajjar KB, Patel II, Taylor S, Martin-Hirsch PL, Stringfellow HF, Martin FL, Phillips DH.Br J Cancer. © 1996-2020 MDPI (Basel, Switzerland) unless otherwise stated Alternating progesterone and tamoxifen is an option that seems to work well and be better tolerated than progesterone alone. 2014 Nov 1;74(21):6205-15. doi: 10.1158/0008-5472.CAN-14-1716. Name must be less than 100 characters (44) reported on 11 women who developed endometrial cancer during tamoxifen treatment of 20 mg/d for 2: 18 months. You seem to have javascript disabled. 1994 Jul;13(3):248-58. doi: 10.1097/00004347-199407000-00009.Cancers (Basel). It might also be used to treat advanced or recurrent endometrial cancer. Our dedicated information section provides allows you to learn more about MDPI.
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