Hippocrates used the “aspirin” in willow bark powder to treat pain and fever thousands of years ago. Researchers only asked about aspirin use once, for example, at the start of the study, so people who stopped taking aspirin might have been misclassified.
Age-related macular degeneration (AMD) is becoming the leading cause of blindness in developed countries. Researchers reviewed the records of nearly 200 eyes of patients whose average age was 83. That was true even after researchers accounted for other things known to influence a personâs risk for macular degeneration, including age, The study doesnât prove that aspirin causes macular degeneration. A number of risk factors of AMD have been recognized, such as cigarette smoking, a family history of AMD and being Caucasian. Beyond age, the only risk factor thatâs consistently been linked to the condition is News that aspirin may be linked to macular degeneration surfaced last year when a large European study found that regular aspirin users were more likely to develop the sight-stealing disease. MACULAR DEGENERATION AND ASPIRIN USE Overall, the number, size, and quality of the cardiovascular studies recommending aspirin use are far superior to the fewer, smaller and conflicting studies suggesting a possible adverse effect of aspirin use in relation to AMD. Julie Heraghty, CEO of the Macular Degeneration Foundation welcomes these research findings but cautions that we need more studies to see if the finding is consistent. "The cumulative incidence of neovascular AMD among non regular aspirin users was 0.8 percent at five years, 1.6 percent at 10 years, and 3.7 percent at 15 years," said the director of WMI's Centre for Vision Research, Professor Paul Mitchell. Millions of people with Both kinds of macular degeneration become more common as people age. "WMI report's authors note that any decision concerning whether to stop aspirin therapy is "complex and needs to be individualised. These drusen, essentially represent the “garbage by products” of the retina and over time the deposits can interfere with the function of the macula. Different kinds of studies are needed to understand whether aspirin may directly harm the But one theory is that aspirin ramps up a part of the immune system called the complement system. The risk of getting macular degeneration after 15 years of regular aspirin use was still relatively slight. It was more than four times as high for regular vs. non-regular users, suggesting that there might be a biological basis for the association.But other limitations make the findings less reliable. The exact etiology and pathophysiology of AMD is still unclear. ""Currently, there is insufficient evidence to recommend changing clinical practice, except perhaps in patients with strong risk factors for neovascular AMD (e.g., existing late AMD in the fellow eye) in whom it may be appropriate to raise the potentially small risk of incident neovascular AMD with long-term aspirin therapy," the authors conclude.Julie Heraghty, CEO of the Macular Degeneration Foundation welcomes these research findings but cautions that we need more studies to see if the finding is consistent. However, it is still not enough evidence to show a causal link," she said.
Patients with macular degeneration, for heart and other conditions are receiving antiplatelet and anticoagulant medications such warfarin, and clopidogrel run a higher risk of retinal hemorrhage or over-the-counter drugs such as aspirin than people who do not. Nearly 1/2 of … Continue reading "Macular … The benefits of aspirin usage include preserving the duration and quali … ""In Professor Paul Mitchell we are fortunate in Australia to have one of the world leading experts in this field and we need to fund this type of research to find more reasons and answers to this devastating disease," she said.Note: Professor Mitchell was an inaugural recipient of the Macular Degeneration Foundation Research Grants program in 2011, for a separate project.
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