Common side effects of Zanaflex include: bradycardia, dizziness, drowsiness, hypotension, asthenia, fatigue, and xerostomia. FDA Prescribing InformationWhat are the important side effects of Zanaflex (tizanidine)?Zanaflex (tizanidine) side effects list for healthcare professionals The median dose during the plateau phase ranged from 20–28 mg/day.The most frequent adverse reactions reported in multiple dose, placebo-controlled clinical studies involving 264 patients with spasticity were Table 1 lists signs and symptoms that were reported in greater than 2% of patients in three multiple dose, placebo-controlled studies who received Zanaflex where the frequency in the Zanaflex group was greater than the placebo group. Early warning signs and symptoms of MS in children, teens, and adults are similar; however, children and teens with pediatric also may have seizures and a complete lack of energy. uncontrollable periods of laughing or crying. Because it is soluble in lipids, it might pass into breast milk. vitamin D deficiency. A spinal cord injury can have significant physiological consequences. Based on the information provided regarding these reactions, a causal relationship with Zanaflex cannot be entirely excluded. Dry Mouth 8. yellowing of the eyes or skin.
Across the three studies patient ages ranged from 15–69 years and 51.4 percent were women. Urinary Tract Infection For comparison purposes, the corresponding frequency of the event (per 100 patients) among placebo treated patients is also provided.In the single dose, placebo-controlled study involving 142 patients with spasticity due to The following adverse reactions have been identified during post approval use of Zanaflex. clumsiness, muscle cramps and twitches, problems holding objects, and
Dosage can be gradually increased by 2 mg to 4 mg at each dose, with 1 to 4 days between dosage increases, until a satisfactory reduction of … MS in children, teens,
However, if concomitant use is clinically necessary, initiate Zanaflex with a single 2 mg dose and increase in 2–4 mg steps daily based on patient response to therapy. Nervousness 11. Multiple sclerosis does not affect ability to conceive, and does not seem to affect fertility. Call your doctor for medical advice about side effects. Changes in pharmacokinetics of tizanidine when administered with ciprofloxacin resulted in significantly decreased blood pressure, increased drowsiness, and increased psychomotor impairment.Because of potential drug interactions, concomitant use of Zanaflex with other CYP1A2 inhibitors, such as Concomitant use of Zanaflex with oral contraceptives is not recommended. expectancy are different. This damage results in symptoms that may include numbness, weakness, vertigo, paralysis, and involuntary muscle contractions. Symptoms of MS include vision changes, paralysis, vertigo, heat intolerance, slurred speech, sexual dysfunction, and urinary incontinence (the inability to urinate). Dizziness 6. Zanaflex side effects. progresses rapidly and leads to death.Multiple sclerosis or MS is a central nervous system disease in which the immune system attacks the myelin sheath (the protective coating around nerves). ALS occurs between 50-70 years of age (the average
Multiple sclerosis is not a fatal condition, while ALS
Consult your doctor before breastfeeding.Multiple Sclerosis is a debilitating neurological condition. Pregnancy decreases the number of relapses, but flares increase in the first 3-6 months after delivery. age of occurrence ALS is 55), and mostly affects men. system, although it's not considered an autoimmune disease by some
Some treatment MS drugs may be safe to use during pregnancy; however, some drugs should not be taken, for example, baclofen (Gablofen, Lioresal), fluoxetine (Prozac, Sarafem), or solifenacin succinate (VESIcare), and most disease-modifying therapies (DMTs). Feeling tired or weak. Tell your doctor or health care professional if your symptoms do not start to get better or if they get worse. different from ALS include vision problems, vertigo and balance problems, sexual
Because the effect of Zanaflex peaks at approximately 1 to 2 hours post-dose and dissipates between 3 to 6 hours post-dose, treatment can be repeated at 6 to 8 hour intervals, as needed, to a maximum of three doses in 24 hours. Zanaflex Side Effects. MS is an autoimmune
Call your doctor at once if you have: a light-headed feeling, like you might pass out; weak or shallow breathing; confusion, hallucinations; or. Symptoms of MS include pain, sexual problems, fatigue, numbness and tingling, emotional changes, and depression.Women who are pregnant and have multiple sclerosis may have more difficulty carrying a pregnancy. About 30,000 people in the US have ALS,
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