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If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Get started! I have been given a prescription for trimovate and antibiotics. People have varying gastric pHs on empty stomachs, and thus absorption from one person to another can vary wildly when taken without food.Absorption is also affected by how much of the albendazole is degraded within the small intestine by metabolic enzymes in the villi.The pharmacokinetics of albendazole differ slightly between men and women: women have a lower oral Albendazole undergoes very fast 1st-pass metabolism in all species, such that the unchanged drug is undetectable in plasma.Oxidation to albendazole sulfoxide by FMO produces R(+) Albendazole sulfoxide is converted to the inactive albendazole sulfone by cytochrome P450 oxidases, thought to include CYP3A4There are also some minor hydroxylated sulfated or glucuronidated derivatives.In humans, the metabolites mostly excreted in the bile, with only a small amount being excreted in the urine (less than 1%) and feces.Like all benzimidazoles, albendazole has no residual effect, and thus does not protect well against reinfestations.Albendazole, patented in 1975, was invented by Robert J. Gyurik and Vassilios J. Theodorides and assigned to SmithKline Corporation.In many areas of the world it costs between US$0.01 and US$0.06 per dose.Albendazole is mainly used in cattle and sheep, but has found some use in cats and dogs as well;Albendazole has been used as an anthelminthic and for control of flukes in a variety of animal species, including cattle, sheep, goats, swine, camels, dogs, cats, elephants, poultry, and others.Albendazole has greater bioavailability in ruminants: some albendazole sulfoxide, when released back into the rumen, is reduced to albendazole by the resident microbiota, with a preference of the (+) enantiomer being the substrate.The limitations in early pregnancy are due to a limited period during which teratogenic effects may occur.
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