Aminophylline is a xanthine derivative used as a central nervous system stimulant in the management of Apnoea of Prematurity. Elderly patients also appear to be more sensitive to the toxic effects of theophylline after chronic overdosage than younger patients. We comply with the HONcode standard for trustworthy health information - The aminophylline dose used for intravenous loading (5 mg/kg) in the UK and Eire does not achieve the therapeutic range expected by clinicians in most patients. 500mg/vial; Gout. Theophylline demethylation to 3-methylxanthine is catalyzed by cytochrome P-450 1A2, while cytochromes P-450 2E1 and P-450 3A3 catalyze the hydroxylation to 1,3-dimethyluric acid. Administer multiple-dose oral activated charcoal and measures to control emesis.3. Syringe: Doxapram.
Different rates of elimination and consequent dosage requirements have been observed among other peoples. (See DOSAGE AND ADMINISTRATION. 3-methylxanthine has approximately one tenth the pharmacologic activity of theophylline and serum concentrations in adults with normal renal function are less than 1 mcg/mL. Monitor the patient and obtain serial theophylline concentrations every 2 - 4 hours to gauge the effectiveness of therapy and to guide further treatment decisions.3. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer. Clinically important improvement in symptom control and pulmonary function has been found in most studies to require serum theophylline concentrations greater than 10 mcg/ mL. If a loading dose is not indicated (i.e., the serum theophylline concentration is greater than or equal to 10 mcg/mL), a second measurement should be obtained as above at the appropriate time after starting the intravenous infusion. Institute extracorporeal removal if emesis, seizures, or cardiac arrhythmias cannot be adequately controlled (see OVERDOSAGE, Extracorporeal Removal).C. * These data are derived from two studies in patients with serum theophylline concentrations greater than 30 mcg/mL. [See USP Controlled Room Temperature.] THEO : Theophylline and its congener, aminophylline, are used to relax smooth muscles of the bronchial airways and pulmonary blood vessels to relieve and prevent symptoms of asthma and bronchospasm. In contrast, the large fraction of the theophylline dose excreted in the urine as unchanged theophylline and caffeine in neonates requires careful attention to dose reduction and frequent monitoring of serum theophyllineIn a patient who has received no theophylline in the previous 24 hours, a loading dose of intravenous theophylline of 4.6 mg/kg (5.7 mg/kg as aminophylline), calculated on the basis of ideal body weight and administered over 30 minutes, on average, will produce a maximum post-distribution serum concentration of 10 mcg/mL with a range of 6-16 mcg/ mL. Loading dose (to achieve a target serum concentration of 10 mcg/mL theophylline): For patients with NO theophylline use in the previous 24 hours : -5.7 mg aminophylline/kg (ideal body weight) intravenously over 30 minutes Available for Android and iOS devices. Aminophylline Hydrate (dihydrate) is approximately 79% of anhydrous theophylline by weight. In general, these recommendations should serve as the upper limit for dosage adjustments in order to decrease the risk of potentially serious adverse events associated with unexpected large increases in serum theophylline concentration.
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