Decisions about which treatment to use should include risk management considerations such as ease of prescription, preparation and administration factors and availability of high-dependency beds. When using adenosine for diagnostic studies, discontinue theophylline derivatives 5 half-lives prior to test.Alcohol (Ethyl): May increase the serum concentration of Aminophylline.Allopurinol: May increase the serum concentration of Theophylline Derivatives.Amifampridine: Agents With Seizure Threshold Lowering Potential may enhance the neuroexcitatory and/or seizure-potentiating effect of Amifampridine. It is recommended that …
Management: Seek alternatives when possible. Since adenosine-induced side effects are short lived after discontinuation of the infusion, aminophylline administration is only very rarely required (ASNC [Henzlova 2016]).Vesicant; ensure proper needle or catheter placement prior to and during IV infusion. Theophylline clearance is decreased ≥50% in these patients. Copyright(c) 2016 First Databank, Inc.Are you considering switching to Aminophylline Ampul?Are you planning to see a doctor about switching your medication?Are you planning to see a doctor about switching your medication?Selected from data included with permission and copyrighted by First Databank, Inc. Monitor for toxic effects of theophylline derivatives if a macrolide is initiated/dose increased. Aminophylline systemic 100 mg (West-Ward 020) Loading doses should be administered IV over 30 minutes. 0
When therapeutic doses of Aminophylline and/or theophylline are administered simultaneously by more than one route or in more than one preparation, the hazard of serious toxicity is increased. Antithyroid Agents: May increase the serum concentration of Theophylline Derivatives.AtoMOXetine: May enhance the hypertensive effect of Sympathomimetics. Find patient medical information for Aminophylline Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. We comply with the HONcode standard for trustworthy health information - As the rate of theophylline clearance may be dose-dependent, an increase in dose based upon a subtherapeutic serum concentration measurement should be limited to ~25% increase of the previous infusion rate or daily dose.Heart rate; CNS effects (insomnia, irritability); respiratory rate (COPD patients often have resting controlled respiratory rates in low 20s); arterial or capillary blood gases (if applicable)Theophylline levels: Serum theophylline levels should be monitored after initiation of therapy and prior to making dose increases; in the presence of signs or symptoms of toxicity; or when a new illness, worsening of a present illness, or change in patient’s treatment regimen that may alter theophylline clearance (eg, fever Loading dose: Measure serum concentrations 30 minutes after the end of an IV loading dose in patients who have not received theophylline in the previous 24 hours to determine the need for an additional loading (serum concentration <10 mcg/mL) or to delay starting the constant IV infusion (serum concentration >20 mcg/mL).Infusion: Measure serum concentrations one half-life (eg, ~4 hours in children 1 to 9 years of age or 8 hours in nonsmoking, otherwise healthy adults) after starting a continuous infusion, then every 12 to 24 hours for duration of infusion; measure more frequently in acutely ill patients.Aminophylline is a complex of theophylline and ethylenediamine.
In patients with cor pulmonale, cardiac decompensation, hepatic impairment, patients >60 years of age, or patients taking medications that reduce theophylline clearance, the initial maintenance infusion rate should not exceed 21 mg/hour.Off-label use: For reversal of adenosine-, dipyridamole-, or regadenoson-induced adverse events during nuclear cardiac stress testing, administer IV undiluted over 30 to 60 seconds, repeat as necessary. Les propriétés pharmacologiques de l'aminophylline sont celles de la théophylline. Beta-Blockers (Beta1 Selective): May diminish the bronchodilatory effect of Theophylline Derivatives. If this is not feasible, give the drug through as large a vein as possible (for example median cubital) or via a suitable long-line, inserted peripherally.Further increases should be based on clinical response.Initially 5microgram/minute adjusted according to response and heart rate.
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