Any CYP3A4 substrate used with stiripentol requires closer monitoring.Tacrolimus (Systemic): Calcium Channel Blockers (Dihydropyridine) may increase the serum concentration of Tacrolimus (Systemic). Avoid cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus, and tacrolimus.Mitotane: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers). If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects).Dapoxetine: May enhance the orthostatic hypotensive effect of Calcium Channel Blockers.Deferasirox: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).Dexmethylphenidate: May diminish the therapeutic effect of Antihypertensive Agents.Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Dofetilide: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Dofetilide. Females with preexisting hypertension may continue their medication during pregnancy unless contraindications exist (ESC [Regitz-Zagrosek 2018]).• It is used to treat some types of chest pain (angina).• It may be given to you for other reasons.
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Nicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents.NiMODipine: CYP3A4 Inhibitors (Weak) may increase the serum concentration of NiMODipine. Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane.Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Naftopidil: May enhance the hypotensive effect of Blood Pressure Lowering Agents.Netupitant: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Neuromuscular-Blocking Agents (Nondepolarizing): Calcium Channel Blockers may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents (Nondepolarizing).
Select one or more newsletters to continue. Management: Dose of simvastatin should not exceed 20 mg daily if coadministering with levamlodipine or amlodipine. Management: Reduce amlodipine dose by at least 50% and monitor for increased amlodipine effects (eg, hypotension) if an antihepaciviral combination product is initiated.Antipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]). Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).Triazolam: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Triazolam. Use of enzalutamide and any other CYP3A4 substrate should be performed with caution and close monitoring.Erdafitinib: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).Erdafitinib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Flibanserin: CYP3A4 Inhibitors (Weak) may increase the serum concentration of Flibanserin. 2184611-overview
Rifamycin Derivatives: May decrease the serum concentration of Calcium Channel Blockers.
Macrolide Antibiotics: May decrease the metabolism of Calcium Channel Blockers. Management: The maximum recommended dosage of lemborexant is 5 mg, no more than once per night, when coadministered with weak CYP3A4 inhibitors.Levodopa-Containing Products: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa-Containing Products.
Duvelisib: May increase the serum concentration of CYP3A4 Substrates (High risk with Inhibitors).Efavirenz: May decrease the serum concentration of Calcium Channel Blockers.Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates (High risk with Inducers).
Brigatinib may enhance the bradycardic effect of Antihypertensive Agents.Brimonidine (Topical): May enhance the hypotensive effect of Blood Pressure Lowering Agents.Bromperidol: May diminish the hypotensive effect of Blood Pressure Lowering Agents.
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