"The speculation that ACE-inhibitors or ARBs treatment can make infections worse in the context of COVID-19 is not supported by clinical evidence," the EMA reiterated. ACE inhibitors and ARBs are safe to use. This study provides further reassurance that their use is safe and that it is important that patients continue to take them as prescribed to protect cardiovascular health.”Patient data included demographics, emergency department letters, discharge summaries, clinical notes, radiology reports, medication orders, and lab results and was retrieved from the structured and unstructured components of the electronic health record (EHR) and analysed using CogStack, an information retrieval and extraction platform.CogStack was developed by researchers at the NIHR Maudsley Biomedical Research Centre and uses enterprise search, natural language processing, analytics and visualisation technologies to unlock health records to assist in clinical decision making and research.CogStack implements new data mining techniques within NHS Trusts – specifically, the ability to search any clinical data source (unstructured and structured), and natural language processing (NLP) applications developed to automate the extraction of medical concepts.
The Coronavirus Disease 2019 (COVID-19) pandemic has killed >129,000 Americans as of June 30, 2020. Some have speculated that treatment with ACEIs and ARBs may be at least in part responsible for the increased severity and mortality from COVID-19 in those with these co-morbidities.COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which enters human cells by binding its spike protein (S) to the angiotensin converting enzyme-2 (ACE2) cell receptor via a protease dependent mechanism (Clinical studies to examine the risk associated with ACEI and ARB treatment in patients with COVID-19 are increasing but remain limited, and data on the individual risk of these agents are even more limited. While the present study reassures, he awaits the publication of BRACE CORONA to sort through its details. The worry was that use of ACE inhibitors and ARBs would increase the expression of ACE2 in the respiratory tract, which would lead not only to an increased risk of becoming infected, but also an increased risk of complications or death among infected patients. Some Clues and PredictionsRisk of Dying Doubled in Wuhan COVID-19 Patients With Hypertension COVID-19, ACE Inhibitors, and ARBs: Multiple Studies Show No Increased Risk CRF is committed to igniting the next wave of innovation in research and education that will help doctors save and improve the quality of their patients’ lives.
Researchers have found ACE inhibitors (a type of blood pressure medicine commonly used in patients with high blood pressure or diabetes) and ARBs (used to treat heart failure and high blood pressure) did not increase the severity of COVID-19 disease in patients in two hospitals.The researchers from King’s College London, King’s College Hospital, NIHR Maudsley Biomedical Research Centre and the London Medical Imaging and Artificial Intelligence Centre for Value Based Healthcare, tested for an association between a patient’s treatment with blood pressure drugs (Angiotensin-converting enzyme inhibitors (ACE Inhibitors) or Angiotensin receptor blockers (ARBs)) and their severity of coronavirus disease.The study used CogStack, an information retrieval and extraction platform, to review the electronic health records of COVID-19 patients.
We’re the BHF. Say no to cocoa and help us raise money to power our life saving research. These data are even more important in light of the recent Surgisphere controversy where researchers found no risk of in-hospital mortality with RAAS inhibition in nearly 9,000 patients, but that study was retracted and largely presumed to be based on fabricated data.To TCTMD, Itchhaporia said that early on the in the pandemic when data was hard to come by and things were changing so rapidly, physicians were looking for guidance on how to best manage patients with COVID-19. Lopes noted that 52% of patients were considered obese (mean BMI 31 Following the Hot Line presentation, Gianfranco Parati, MD (University of Milan-Bicocca/San Luca Hospital, Italy), said the evidence is a welcome addition, congratulating the researchers for conducting the randomized trial during the height of the pandemic. These tools allow clinical text to be searched for specific terms using simple or complex syntax, rapidly retrieving the data needed to answer complex queries such as “find all patients with coronavirus symptoms” or “find all coronavirus patients prescribed ARBs”.Angiotensin-converting enzyme (ACE) inhibitors reduce a person's blood pressure by relaxing their blood vessels. Strand United Kingdom 8 July 2020 London The researchers at Kings College London found that there was no link between the use of angiotensin-converting enzyme (ACE) inhibitors, used to treat blood pressure or diabetes, and the severity of Covid-19.
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