Q ET >> Patients taking digoxin should be monitored appropriately.Co-administration of atorvastatin with an oral contraceptive produced increases in plasma concentrations of norethindrone and ethinyl oestradiol.In a clinical study in patients receiving chronic warfarin therapy, co-administration of atorvastatin 80 mg daily with warfarin caused a small decrease of about 1.7 seconds in prothrombin time during the first 4 days of dosing which returned to normal within 15 days of atorvastatin treatment. ET >>
>> /F3 23 0 R <2910> Tj >> /Widths [ 600 631 520 633 277 612 317 634 549 611 974 634 615 392 633 524 317 684 294 575 634 277 591 411 612 634 698 317 611 274 390 390 317 ] 0 0 0 rg
Q Because of the potential for serious adverse reactions, women taking Atorvastatin should not breast-feed their infants (see section 4.3).Atorvastatin is contraindicated during breastfeeding (see section 4.3).In animal studies atorvastatin had no effect on male or female fertility (see section 5.3).Atorvastatin has negligible influence on the ability to drive and use machines.In the atorvastatin placebo-controlled clinical trial database of 16,066 (8755 Atorvastatin vs. 7311 placebo) patients treated for a mean period of 53 weeks, 5.2% of patients on atorvastatin discontinued due to adverse reactions compared to 4.0% of the patients on placebo.Based on data from clinical studies and extensive post-marketing experience, the following table presents the adverse reaction profile for Atorvastatin.Estimated frequencies of reactions are ranked according to the following convention: Common (≥1/100 to <1/10) Uncommon (≥1/1,000 to <1/100), Rare (≥ 1/10,000 to < 1/1,000) Very rare (≤1/10,000), not known (cannot be estimated from the available data).Uncommon: dizziness, paraesthesia, hypoesthesia, dysgeusia, amnesia.
Intake of one 240 ml glass of grapefruit juice also resulted in a decreased AUC of 20.4% for the active orthohydroxy metabolite. 107 562.40000 Td The risk of these events may be increased with the concomitant use of fibric acid derivatives and atorvastatin.
107 154.40000 Td /F4 11 Tf [ <0b> 4 <13> -2 <1415> -1 <161718> 7 <13> -2 <17> 9 <13> -2 (\031) 4 (\032) 1 <17> -8 <06> -4 <0f> 7 (\033\034) 4 <171a> -7 <06> -4 <03> 4 (\035) -1 (\032) 1 (\035) -1 <15> -1 (\031) 4 (\036) 7 (\030) -10 <06> 5 <05> -1 <13> -2 <171c> 4 (\031) 4 <17> -8 <06> 5 <262006> -4 (\041) -2 <2206> 5 (\036) 7 <1421> -11 (\043) 11 <15> 7 (\035) 7 (\030) 7 (\030) 7 (\035) -20 <06> 5 <15> -1 (\031) 4 <161d> -1 (\030) 7 <13> -2 (\031) 4 <13> -2 (\035) -1 <06> -4 (\036) 7 <141a> -7 <06> 5 (\044) -2 (\031) 4 (\034) 4 (\041) ] TJ /EGS5 12 0 R q 71 321 Td 206.90000 498.10000 Td
71 346.30000 Td /F1renamed << Q ET << q Q /CS /DeviceRGB This risk, however, is outweighed by the reduction in vascular risk with statins and therefore should not be a reason for stopping statin treatment. 99.40000 498.10000 Td /FirstChar 0 Q /F4 11 Tf << ET /F1 24 0 R BT Q 0 0 0 rg BT 274.40000 692 Td [ (\037) 9 (\056) -13 <06> 5 (\057) 4 (\053) 1 (\035) -11 <06> 5 (\036) 7 <1418> 7 (0) -4 (1) -11 <06> 23 <0b> 40 <13> -2 <1415> -1 <161718> 7 <13> -2 <1713> -2 (\031) 4 (\032) 1 <17> -8 <06> 5 <0f> -1 (\033\034) 4 <171a> -7 <06> 5 <03> 4 (\035) -1 (\032) 1 (\035) -1 <15> -1 (\031) 4 (\036) -1 (\030) -10 <06> 5 <05> -1 <13> 6 <171c> 4 (\031) 4 <17> ] TJ LDL apheresis) or if such treatments are unavailable.Prevention of cardiovascular events in adult patients estimated to have a high risk for a first cardiovascular event (see section 5.1), as an adjunct to correction of other risk factors.The patient should be placed on a standard cholesterol-lowering diet before receiving Atorvastatin and should continue on this diet during treatment with Atorvastatin.The dose should be individualised according to baseline LDL-C levels, the goal of therapy, and patient response.The usual starting dose is 10 mg once a day. BT 71 113.30000 Td
W* If the dose of atorvastatin is changed or discontinued, the same procedure should be repeated. >> Q The dose titration to 80 mg daily is supported by study data in adults and by limited clinical data from studies in children with Heterozygous Familial Hypercholesterolemia (see sections 4.8 and 5.1).There are limited safety and efficacy data available in children with Heterozygous Familial Hypercholesterolemia between 6-10 years of age derived from open-label studies.Atorvastatin is not indicated in the treatment of patients below the age of 10 years. /Tr4 11 0 R /F4 11 Tf ciclosporin, telithromycin, clarithromycin, delavirdine, stiripentol, ketoconazole, voriconazole, itraconazole, posaconazole and HIV protease inhibitors including ritonavir, lopinavir, atazanavir, indinavir, darunavir, In cases where co-administration of these medicinal products with atorvastatin is necessary, the benefit and the risk of concurrent treatment should be carefully considered. /Type /Font >> BT
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