However, there are some limitations to our study. We are no longer recommending the use of consent forms for hormone therapy. It is thought low levels of B12 may contribute to low mood or depression (For safety, regular Liver Function Tests (LFT) and prolactin tests are recommended when taking CPA. However, estrogen levels in non-transgender women may not be associated with specific secondary sex characteristics (i.e. I've been on spironolactone over a year and just read on Tumblr that bicalutamide is better but it wasn't said in what ways is it better.. Can someone explain this to me? [37] Another study found a rate of HSDD in transgender women of 34%, compared to 23% in non-transgender women. [26] Consensus is lacking on the role of free vs. total testosterone levels; total testosterone levels are reliable and readily available, however they do not describe the actual bioavailable testosterone level. However, all patients were treated by the same physician and difference in dose likely represented a temporal change in practice and not patient-related features. Antigonadotropic. Likely predictive factors of speed and degree of feminization include genetics, age at initiation of therapy, and body habitus. Typically, you'll begin feminizing hormone therapy by taking the diuretic spironolactone (Aldactone) at doses of 100 to 200 milligrams daily. However, on the other hand, it is not clear how much T blocking power CPA will provide at such a dose.In theory 10 mg CPA could be combined with a lower dose of a second AA such a spironolactone or bicalutamide (so as to increase overall T blocking at the receptor level).
If a conventional LFT where blood is drawn from a vein is difficult to obtain, then find a lab which offers a home based finger prick LFT blood test (which canl be sent both ways by postal mail).A dosage of 25 mg/day would surely be maximal in the effect of suppression of gonadal testosterone, although androgen receptor blockade would not be maximal at that dosage.This point above is worth highlighting and clarifying.With a dose of between 10-25 mg CPA, it is likely there will be a potent T suppressing effect. heparin or compression devices). Many other common interventions such as contraception or HIV pre-exposure prophylaxis do not involve the use of consent forms, and rely on a discussion and shared decision making between patient and provider. Before 2015, there were only a few mentions in the literature of bicalutamide for transfeminine people ( Reddit ) and a handful of anecdotal reports online of transfeminine people using it. The starting dose of Bica though is 50mg. [34]Alkaline phosphatase, hemoglobin and hematocrit (H&H), and creatinine may vary depending on the patient's current sex hormone configuration. Other reasons for measuring hormone levels in the maintenance phase include significant metabolic shifts such as the onset of diabetes or a thyroid disorder, substantial weight changes, subjective or objective evidence of virilization, or new symptoms potentially precipitated or exacerbated by hormone imbalances such as hot flashes or migraines. First, the transgender women may be at lower risk of breast cancer than non-transgender women. Specifically, it is not possible to select in advance an exact hormone regimen that will predictably allow patients to arrive at a specified configuration of sex characteristics. Testosterone has been associated with overall immune suppression, and autoimmune conditions are more common in non-transgender women than men. [24,25] This may explain dose independent reasons why some patients "feel different" on different forms of estrogen.Testosterone levels can be difficult to measure in non-transgender men due to rapid fluctuations in levels, relating to pulsatile release of gonadotropins, with higher levels in the morning hours. Further studies are warranted to explore these findings.To our knowledge, this is the first study to show that a lower dose of CPA (25 mg) in transgender women maintains adequately suppressed testosterone. (there's also GnRH Agoninsts, that tell your brain to stop sending the signal to your junk to make T)Well I enjoy having a working downstairs department snd I already have some slight issues with my plumbing. Postoperative depression is a nontrivial concern and may have some basis in the drastic hormone shifts, including cessation of estrogens, experienced in the perioperative period.
Trying to get all my ducks in a row before seeing the doctor to request HRT. Some people can tolerate it, some people can't. [20] Prior studies reporting a 20 to 40 fold increased risk of VTE in transgender women involved the use of high doses (100-200mcg/day) of thrombogenic ethinyl estradiol in a mix of smokers and non-smokers. This assay also measures minor estrogens such as estriol and estrone. Close • Posted by 4 minutes ago. There is no evidence that higher estradiol levels in patients with adequate androgen suppression results in additional feminization or breast development. [46] Sublingual administration requires insuring that the estradiol tablets are micronized; while most commonly available estradiol tablets are micronized, specifying as such on the written prescription (or consulting with the dispensing pharmacist) is recommended.There is also some limited evidence to suggest that the risk of VTE in menopausal women may be driven more by the choice of progestogen, and that pregnane derived progestogens such as medroxyprogesterone in combination with oral estradiol does not confer an increased risk, while norpregnane derived progestogens such as norethindrone may increase risk by 80% when used with oral estradiol.
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