In Japan, as a single tablet of losartan 50 mg/HCTZ 12.5 mg received marketing approval in December 2006, this single tablet was used; however, as a single tablet of telmisartan/HCTZ has not received marketing approval yet, these 2 drugs were Patients with only 1 observation either before or after the switch were excluded.
Chuo-ku, Chiba, Japan Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 17. Losartan doesn’t appear to work as well as olmesartan or telmisartan at lowering diastolic blood pressure (the second number in your blood pressure reading). Pfeffer MA, McMurray JJ, Velazquez EJ, et al; Valsartan in Acute Myocardial Infarction Trial Investigators. 20. Chuo-ku, Chiba, Japan Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1. For those patients who were to continue ARB therapy via a switch to either losartan or valsartan, dosing guidelines were created by the Veterans Integrated System Network 7 to facilitate the change.
VHA Pharmacy Benefits Management–Strategic Healthcare Group and Medical Advisory Panel. 13.
Epub 2012 Jan 17. Potential options for this therapeutic change included valsartan, losartan, ACE inhibitor therapy (if the patient had no prior history of ACE inhibitor use), or an antihypertensive agent from a class other than ACE inhibitors or ARBs (if the patient had no compelling indication for ACE inhibitor or ARB therapy). PROGRESS Collaborative Group. Telmisartan is an angiotensin-II-type-1-receptor antagonist that very recently has been described to possess the specific properties of a partial activator of PPARγ (13). Morning and office blood pressures (BPs) were significantly reduced (morning, −10.1 ± 10.5/−4.5 ± 8.4 mm Hg; office, −13.1 ± 17.3/−6.2 ± 11.3 mm Hg) after medication change. Conlin PR, Gerth WC, Fox J, Roehm JB, Boccuzzi SJ. This study reviewed the cases of patients from Dorn and its outlying community-based outpatient clinics (CBOCs) who made this ARB switch to determine if the new ARB dosing provided BP control equivalent to that of the previously used irbesartan regimen. The presence of comorbid conditions was determined based on whether particular conditions were documented within patients' medical records. Seventy-eight mild to moderate hypertensive patients, who were treated with the standard doses of ARBs except candesartan (losartan, 50 mg; valsartan, 80 mg; telmisartan, 40 mg; or olmesartan, 20 mg), were entered into 12-week treatment period with candesartan 8 mg according to a multicenter, open-label design. 2012;34(2):86-91. doi: 10.3109/10641963.2011.628729. 19. Demographic data such as age, race, sex, and comorbidities were also recorded. It was expected that this ARB switch had the potential to affect >600 patients at Dorn and its affiliated CBOCs.
Target BPs (morning BPs ≤ 135/85 mm Hg and office BPs ≤ 140/90 mm Hg) achievement rates were 42.9% in the morning and 64.3% at office. Chuo-ku, Chiba, Japan Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, No adverse events were recognized in all patients. Department of Health Services Management, National School of Public Health, Athens, GreeceDepartment of Health Services Management, National School of Public Health, Athens, GreeceDepartment of Health Services Management, National School of Public Health, Athens, GreeceDepartment of Health Services Management, National School of Public Health, Athens, GreeceDepartment of Health Services Management, National School of Public Health, Athens, GreeceDepartment of Health Services Management, National School of Public Health, Athens, GreeceUse the link below to share a full-text version of this article with your friends and colleagues.
Despite these concerns, we believe that using a doubly multivariate, repeated-measure, mixed-model ANOVA for BP and a repeated-measure, mixed-model ANOVA for serum creatinine and serum potassium levels provided sufficient power to determine whether even a small difference between treatment groups existed. Suita, Osaka, Japan/doi/full/10.3109/10641963.2011.628729?needAccess=true Read our disclaimer for details. Patients who switched from irbesartan to an ACE inhibitor (eg, lisinopril, fosinopril, or ramipril) or to any drug other than valsartan or losartan were excluded from the study. 6. A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure. Chuo-ku, Chiba, Japan Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, To be included, patients must have been switched from irbesartan 150 mg once daily to valsartan 80 mg or losartan 50 mg once daily or from irbesartan 300 mg once daily to valsartan 160 mg or losartan 100 mg once daily according to the VISN 7 guidelines.
These guidelines suggested that patients taking irbesartan 150 mg once daily be treated with either valsartan 80 mg or losartan 50 mg once daily and that patients taking irbesartan 300 mg once daily be treated with either valsartan 160 mg or losartan 100 mg once daily. Age-specific relevance of usual blood pressure to vascular mortality: A meta-analysis of individual data for one million adults in 61 prospective studies [erratum in 4.
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