J Pharmacol Exp Ther 2002; 303:218. Drug reported in the product labelling to prolong the QT interval, but evidence to support such an effect is lacking or published data suggest otherwise. If you notice other effects not listed above, contact your doctor or pharmacist. Clipboard, Search History, and several other advanced features are temporarily unavailable. Information last revised April 2015. A safe drug in one patient may be potentially harmful in another. A total of four of the 20 adults received cisapride and three received disopyramide. The lowest GoodRx price for the most common version of clarithromycin is around $17.93, 84% off the average retail price of $112.74. Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. This site uses cookies. Three adults were considered to suffer from some aspect of the congenital long QT syndrome.We believe that the risk factor description for this drug should be refined to emphasize the major risk factors of (1) female sex, (2) old age and (3) heart disease.Clarithromycin is the most widely used macrolide antibiotic in the United Kingdom and is strongly recommended for patients with severe community-acquired pneumonia [Bril and colleagues, in a study of antimicrobial agents linked to QTc interval prolongation, outlined risk factors using a flowchart [In the 1970s, the Japanese drug company Taisho Pharmaceutical developed the macrolide antibiotic clarithromycin aiming to improve on erythromycin’s spectrum of activities, frequency of administration and tolerability [The pharmacokinetics of clarithromycin are similar to those of erythromycin [The postantibiotic effect of clarithromycin varies according to the pathogen [A common feature of drugs associated with acquired long QT syndrome and TdP is their ability to produce pharmacological inhibition of the activity of the hERG (An intriguing aspect of clarithromycin’s ability to inhibit hERG channels is the potential for this action of the drug to vary between individuals. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site.
the site you are agreeing to our use of cookies. eCollection 2018. Initially, we entered the following MeSH terms: ‘clarithromycin and QTc prolongation’ (13) and ‘clarithromycin and torsade’ (10) into Medline. Taking drugs that prolong the QT interval (for example haloperidol, sotalol, terfenadine, and pimozide) — macrolides can also prolong the QT interval, which is a risk factor for Torsades de pointes. The number of non-antiarrhythmic drugs reported to induce QT interval prolongation with or without torsade de pointes continues to increase. Find out about Lean Library If you have access to journal via a society or associations, read the instructions belowAccess to society journal content varies across our titles.If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box.Contact us if you experience any difficulty logging in.Some society journals require you to create a personal profile, then activate your society accountYou are adding the following journals to your email alertsDid you struggle to get access to this article?
Simply select your manager software from the list below and click on download. Limit alcoholic beverages. We propose that sufficient information based on case report analysis exists to presently identify the triad of (1) female sex, (2) old age and (3) heart disease as major risk factors for QTc interval prolongation and TdP among patients about to receive clarithromycin. Examples include certain azole antifungals (such as itraconazole, ketoconazole), rifamycins (such as rifampin, rifabutin), Many drugs besides telithromycin may affect the heart rhythm (QT prolongation), including amiodarone, cisapride, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. I have a pacemaker for intermittent heart block. " Do not prescribe clarithromycin to people with: A history of QT prolongation or ventricular cardiac arrhythmia, including Torsades de pointe arrhythmias.
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