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;�".Hc����=~� ��/��h�Ɗ�Q[��?�^V��3�~��s�����gһ��������K H/�EP��}ى-�L�WUr�喍��uD endobj (b) The quantity of clozapine dispensed must not exceed that which is required to take the patient from the date of dispensing … ��ٵY$�ߐ֑˒��L��}�l��Z5�J�:�S��)�'�ux�3�ɲ2�"�S��JRfK��~)gPzA�D+4�bg �V��!�;H���@t��+�g(¢�J�����Dcb�(�G���^����,�{^&��uO�'G�H��� 2 0 obj 5 0 obj 3, 8 Clozapine can only be dispensed from pharmacies that are contracted to do so and dispensing is prohibited if a blood test with a satisfactory result has not been performed in the previous three days. <> x���]k�P�����ԋ�8�[(�ִ����]ًl�X�j1v���w�U0A�!Ha�����c�����nW)�n���@��A�k1�X��¶�3�'�1XĨ��-E�����c,��M}a��������,�8�)zR�`� �sx�h_�)�ŹbU߲�XT9ԇI�����кN���woE����)���ڝ�g��1�L�{�V�Q���e�^�l^vM����$���$�Y����a�����(?�1䧯��l9R`Gӎ����-B�V ڤ��w��P�� <> endobj %PDF-1.5 1.6 Side effects of clozapine may include: Severe constipation, leading to impaction and obstruction. endobj 6 0 obj 12 0 obj 9 0 obj 8 0 obj endobj
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Clozapine - Guidelines for Prescribing, Administration and Monitoring SESLHDPR/591 Revision: 1 Trim No.
This document provides guidance on clozapine treatment and ensures systems are in place to minimise the clinical risks associated with clozapine. Expert panelists review the causes, diagnostic work-up, management, and emerging therapies inherent in the evolving paradigm of irritable bowel syndrome.The FDA is changing dispensing requirements for the schizophrenia drug clozapine (Clozaril) to address safety concerns about severe neutropenia.The FDA is changing dispensing requirements for the schizophrenia drug clozapine (Clozaril) to address safety concerns about severe neutropenia. <> 3 0 obj 7 0 obj <> Patients taking clozapine require a weekly white blood cell count for the first 18 weeks of treatment and every four weeks thereafter . When dispensing clozapine for the first time, in addition to verifying the patient’s hematological status, the pharmacist should verify the patient’s non-rechallengable status. • Interrupt treatment for suspected clozapine induced neutropenia • Do not rechallenge unless prescriber determines benefits outweigh risks • Weekly from initiation to 6 months • Every 2 weeks from 6 to 12 months • Monthly after 12 months • See Section 2.4 of the full Prescribing Information GENERAL POPULATION • Three times weekly until ANC ≥ 1500/μL • Once ANC ≥ 1500/μL, 10 0 obj endobj 1 0 obj 1.POLICY STATEMENT 3 2.BACKGROUND 3 3.RESPONSIBILITIES 3 … endobj endobj <> It outlines responsibilities and the procedure to be followed when initiating, dispensing, administering and monitoring clozapine treatment. 28 8 Smoking Cessation – effect on clozapine 30 9 Suggested GP letter 32 10 Shared care guideline: information for the GP 34 <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 13 0 R 15 0 R 19 0 R 21 0 R] /MediaBox[ 0 0 595.32 841.92] /Contents 12 0 R/Group<>/Tabs/S/StructParents 1>> (a) Clozapine will generally be dispensed in lots of 7, 14 or 28 days as dictated by the frequency of blood monitoring or the date of the next blood test. endobj <>>> <> endobj Clozapine tablets are indicated for the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment. Pharmacists can call the clozapine networks to assess previous clozapine exposure and risk of … endobj Weekly CBC is required of all patients on clozapine for the first 26 weeks, after which the frequency may be reduced to every two weeks. The FDA is changing dispensing requirements for the schizophrenia drug clozapine (Clozaril) to address safety concerns about severe neutropenia. stream 5 Clozapine in the community contact monitoring sheet 20 6 Guidelines for the management of a red clozapine result 23 7 Guide to Interpretation of Clozapine Plasma Levels. CONTENT . Procedure content cannot be duplicated. 4 0 obj
2 Clarke Drive Suite 100 Cranbury, NJ 08512 P:609-716-7777 F:609-716-9038 T1732283 Date: August 2019 Page 1 of 44 COMPLIANCE WITH THIS DOCUMENT IS MANDATORY This Procedure is intellectual property of South Eastern Sydney Local Health District. Only registered pharmacies can dispense clozapine. The first change involves new prescribing information that clarifies how health care professionals should manage clozapine treatment and … <> endstream Myocarditis/cardiomyopathy Disturbed glucose control and diabetes 1.7 Omission of clozapine for more than 48hours necessitates re-titration of the dose starting at 12.5mg or 25mg/day; during which frequent monitoring of physical parameters is … endobj <> x��Z�n�F}7��G2���+I P�I��i�XA�&}�eJ& ��('p��3CR"m�ڸT�w8�3�g�f���˗��.�^����d5g^�:�t��z�.�.�������`2��f���`| JH�B�V� ��u����I�M�X�C��B�l3�ը{��/�'���|�M}㭶����vz�l��ڢЖ�Q��g�5d��w���_���.(ъC2!
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