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The success rate in reducing corticosteroid to prednisone ≤10 mg/d within 6 months, while maintaining control of ocular inflammation, was 89.7% (95% confidence interval [CI], 81.1–93.5%). 0000002390 00000 n
Cyclophosphamide 15mg/kg (max1g) slow infusion over 30 minutes. CLINICAL TRIAL PROTOCOL - CYCLOPS Randomised trial of daily oral versus pulse Cyclophosphamide as therapy for ANCA-associated Systemic Vasculitis Summary The primary, ANCA-associated systemic vasculitides (AASV), including Wegener’s granulomatosis and microscopic polyangiitis, are progressive, multisystem, autoimmune diseases which respond to
RESULTS: 32 SLE patients with lupus nephritis were recruited: 16 were randomised to intermittent pulse cyclophosphamide and 16 to continuous cyclophosphamide plus azathioprine. 2. 0000126542 00000 n
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Chlorphenamine oral - Dose as per CBNF 5. 0000151541 00000 n
Cyclophosphamide must be given on weeks 0, 2, 4, 7, 10 and 13. 0000126284 00000 n
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Illei GG, Austin HA, Crane M, Collins L, Gourley MF, Yarboro CH, et al.
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Cyclophosphamide pulse therapy in idiopathic pulmonary fibrosis M. Kolb, J. Kirschner, W. Riedel, H. Wirtz, M. Schmidt aa Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with a poor response to therapy and a prognosis similar to malignancies; the 5-yr survival rate is estimat-ed at only 50% [1–4]. 0000181517 00000 n
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It also allows tapering and discontinuing corticosteroids in most patients. To analyze the success rate of pulsed intravenous (IV) cyclophosphamide (CyP) for noninfectious ocular inflammatory disease and to identify risk factors for failure of therapy.Retrospective, interventional, noncomparative cohort study.Through a computer search of the Massachusetts Eye Research and Surgery Institution’s database, we identified patients who were treated with IV CyP between May 2005 and April 2012. Handle and dispose of cyclophosphamide in a manner consistent with other cytotoxic drugs.
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Risk for sustained amenorrhea in patients with systemic lupus erythematosus receiving intermittent pulse cyclophosphamide therapy. Early initiation of therapy during the course of the disease was correlated with a lesser rate of recurrence (Pulsed IV CyP employing our protocol results in an extremely high rate of sustained complete remission in patients with recalcitrant and fulminant, vision-threatening ocular inflammatory disorders, with an excellent safety profile in the hands of physicians trained and skilled in the art of this therapy. 0000179113 00000 n
Ann Intern Med 1993; 119:366. 0000047044 00000 n
Published by Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. 1. We obtained demographic and clinical information through review of the electronic health record of each patient.Clinical response, corticosteroid-sparing effect, recurrence rate, calculated “risk factors” for failure, visual acuity, and adverse reactions.Pulsed IV CyP achieved complete remission of inflammation (for ≥2 visits) in 54 patients (84.4%). 0000022414 00000 n
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Chemotherapeutic Agents and Expanded Practice Protocol for the Administration of ... and/or pulse intravenous corticosteroid may also be used at diagnosis at the discretion of the treating Consultant. Therapy must not administer Cyclophosphamide infusions. 0000130900 00000 n
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The mean duration of clinical remission for those patients who had a positive response to CyP was 32.67 months (95% CI, 25.91–39.43). Cyclophosphamide-induced ovarian failure and its therapeutic significance in patients with breast cancer.
Boumpas DT, Austin HA 3rd, Vaughan EM, et al. 0000148446 00000 n
Ann Intern Med.
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Mesna 3mg/kg oral or IV prior to Cyclophosphamide infusion. Early initiation of therapy may decrease the risk of relapses.The authors have no proprietary or commercial interest in any materials discussed in this article.Financial Disclosures: The authors have no commercial or proprietary interest in any materials discussed in this article.We use cookies to help provide and enhance our service and tailor content and ads.
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Koyama H, Wada T, Nishizawa Y, et al.
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