For more information, ask your healthcare provider or pharmacist.Call your doctor for medical advice about side effects. It is presumed that the toxicity results from cumulative dopamine agonist effects.
The first section is about the risk of changes in thinking and behavior, depression and suicidal thoughts or actions with medicines used to quit smoking; the second section is about the risk of suicidal thoughts and actions with antidepressant medicines; and the third section is entitled “What Other Important Information Should I Know About Zyban?”Quitting Smoking, Quit-Smoking Medications, Changes in Thinking and Behavior, Depression, and Suicidal Thoughts or ActionsTalk to your healthcare provider or your family member’s healthcare provider about:New or worse mental health problems, such as changes in behavior or thinking, aggression, hostility, agitation, depression, suicidal thoughts or actions.Stop taking Zyban and call your healthcare provider right away if you, your family, or caregiver notices any of these symptoms.Antidepressant Medicines, Depression and Other Serious Mental Illnesses, and Suicidal Thoughts or ActionsWhat is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions?Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment.Depression or other serious mental illnesses are the most important causes of suicidal thoughts and actions. In patients with mild hepatic impairment (Child-Pugh score: 5 to 6), consider reducing the dose and/or frequency of dosing Consider reducing the dose and/or frequency of Zyban in patients with renal impairment (Glomerular Filtration Rate less than 90 mL per min) Do not start Zyban in a patient who is being treated with a reversible MAOI such as linezolid or intravenous methylene blue. When you give up smoking, expect to feel a strong urge to reach for a cigarette while drinking coffee or tea. Some people can have severe allergic reactions to Zyban. In primate models assessing the positive reinforcing effects of psychoactive drugs, bupropion was self‑administered intravenously.
Infrequent adverse reactions are those occurring in 1/100 to 1/1,000 subjects, while rare events are those occurring in less than 1/1,000 subjects.The following adverse reactions have been identified during post-approval use of Zyban and are not described elsewhere in the label. Is it possible for diarrhea to be the only symptom of colon cancer? They can advise you on how to manage your diarrhoea and might recommend some medicines.Sometimes it can be hard to know when to call your doctor or nurse because you don’t want to bother them. When you try to quit smoking, drinking alcohol may make it even tougher to cope.Here are some tips for the first few weeks after quitting:How can I resist the urge to smoke when I’m feeling bored?When you quit smoking, you may miss the increased excitement and good feeling that nicotine gave you. But, when diarrhea lasts for weeks, it usually indicates that's there's another problem. In some cases, these symptoms abated upon dose reduction and/or withdrawal of treatment. Adverse reactions have included restlessness, agitation, tremor, ataxia, gait disturbance, vertigo, and dizziness. The mean elimination half-life (±SD) of bupropion after chronic dosing is 21 (±9) hours, and steady-state plasma concentrations of bupropion are reached within 8 days.The absolute bioavailability of Zyban in humans has not been determined because an intravenous formulation for human use is not available.
Smoking status and body mass index: A longitudinal study. Patients treated concomitantly with Zyban and such drugs may require increased doses of the drug Coadministration of Zyban with digoxin may decrease plasma digoxin levels.
Pre-existing glaucoma is almost always open-angle glaucoma because angle-closure glaucoma, when diagnosed, can be treated definitively with iridectomy. At least 14 days should elapse between discontinuation of an MAOI and initiation of treatment with Zyban.
Observe patients for the occurrence of neuropsychiatric adverse events. Several side effects are associated with this product. Chronic diarrhea Some infections, food allergies and intolerances, digestive tract problems, abdominal surgery, and long-term use of medicines can cause chronic diarrhea.
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However, it appears likely that only a small proportion of any orally administered dose reaches the systemic circulation intact. This may be particularly true when you are feeling bored.Do nicotine replacement products relieve nicotine cravings and withdrawal symptoms?Yes. Zyban should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Pregnant smokers should be encouraged to attempt cessation using educational and behavioral interventions before pharmacological approaches are used.No increased risk for cardiovascular malformations overall has been observed after bupropion exposure during the first trimester.
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