A prospective study of all patients treated with chemotherapy over a 12-month period was performed.
Zhang J, Kuehl P, Green ED, Touchman JW, Watkins PB, Daly A, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Wrighton SA, Hancock M, Kim RB, Strom S, Thummel K, Russell CG, Hudson Jr JR, Schuetz EG, Boguski MS (2001) The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
This leads to an unpredictable variation in effect. Mathijssen RHJ, Verweij J, Maja JA, de Jonge MJA, Nooter K, Stoter G, Sparreboom A (2002) Impact of body-size measures on irinotecan clearance: Alternative dosing recommendations.
Department of Medical Oncology and Palliative Care, Westmead Hospital, Westmead, 2145, AustraliaYou can also search for this author in
Berch J, Wiklund T, Erikstein B, Lidbrink E, Lindman H, Malmstrom P, Kellokumpu-Lehtinen P, Bengtsson NO, Soderlund G, Anker G, Wist E, Ottosson S, Salminen E, Ljungman P, Holte H, Nilsson J, Blomqvist C, Wilking N (2000) Tailored fluorouracil, epirubicin, and cyclophosphamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer: a randomised trial.
Follow these four steps to easily calculate your patient's accurate drug dosage. One consequence of this, coupled with the inaccuracy of BSA-dosing, is that significant underdosing becomes intrinsic to our system of dose determination. Wrighton SA, VandenBranden M, Ring BJ (1996) The human drug metabolizing cytochromes P450.
It can be used to treat mild or moderate malaria but is not recommended for severe malaria. Gurney H, Dodwell D, Thatcher N, Tattersall MHN (1993) Escalating drug delivery in cancer chemotherapy: A review of concepts and practice – part 1. Gurney H (1996) Dose calculation of anticancer drugs: a review of the current practice and introduction of an alternative. Bishop JF, Dewar J, Toner GC, Smith J, Tattersall MH, Olver IN, Ackland S, Kennedy I, Goldstein D, Gurney H, Walpole E, Levi J, Stephenson J, Canetta R (1999) Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front line therapy in untreated metastatic breast cancer. Cortes EP, Holland JF, Wang JJ, Sinks LF, Blom J, Senn H, Bank A, Glidewell O (1974) Amputation and adriamycin in primary osteosarcoma.
that methods for more accurate dose calculation are determined, based on the known drug elimination processes for cytotoxic chemotherapy.
Scandinavian Breast Group 9401 study. Gurney HP, Ackland S, Gebski V, Farrell G (1998) Factors affecting epirubicin pharmacokinetics and toxicity: evidence against using body-surface area for dose calculation. Identification of drug handling capability before treatment can allow the abandonment of BSA-dosing and avoid serious but often unrecognised underdosing.This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publicationAlexandre J, Bleuzen P, Bonneterre J, Sutherland W, Misset JL, Guastalla J, Viens P, Faivre S, Chahine A, Spielman M, Bensmaine A, Marty M, Mahjoubi M, Cvitkovic E (2000) Factors predicting for efficacy and safety of docetaxel in a compassionate-use cohort of 825 heavily pretreated advanced breast cancer patients.
Hovgaard D, Nissen NI (1992) A phase I/II study of dose and administration of non-glycosylated bacterially synthesized G-M CSF in chemotherapy-induced neutropenia in patients with non-Hodgkin's lymphomas. Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA (2002) Regulation of multidrug resistance-associated protein 2 (MRP2;ABCC2) by the nuclear receptors PXR, FXR, and CAR.
Ratain MJ (1998) Body-surface area as a basis for dosing of anticancer agents: science, myth, or habit?. This is in contrast to the dissimilarity in the dosages per unit of weight for these … Twelve rules for dose calculation of chemotherapy are given that can be used as a guideline until better dose-calculation methods become available.
The calculation for BSA should be standardised and the same method used by all clinicians at the institution. This leads to an unpredictable variation in effect.
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