Other agents seem to cause idiosyncratic reactions that affect only certain susceptible individuals.Some agents (eg, valproic acid, carbamazepine, and beta-lactam antibiotics) act by direct inhibition of myelopoiesis. Managing infections in the immunocompromised patient.
NCCN Clinical Practice Guidelines in Oncology, Myeloid Growth Factors.
Severe neutropenia during cabazitaxel treatment is associated with survival benefit in men with metastatic castration-resistant prostate cancer (mCRPC): A post-hoc analysis of the TROPIC phase III trial. [Guideline] National Comprehensive Cancer Network.
Freifeld A, Marchigiani D, Walsh T, Chanock S, Lewis L, Hiemenz J, et al. Curnutte J, Coates T. Disorder of phagocyte function and number.
Clomipramine.
Tuberculosis was confirmed on sputum testing. About Neutropenia: Neutropenia is a condition of an abnormally low number of a type of a particular type of white blood cell called a neutrophil.White blood cells (leukocytes) are the cells in the blood that play important roles in the body's immune by fighting off infection.
For example, drugs such as the antipsychotics and antidepressants and chloramphenicol may act as direct toxins in some individuals, based on metabolism and sensitivity in this manner. Dranitsaris G, Rayson D, Vincent M, Chang J, Gelmon K, Sandor D, et al. Grann VR, Bowman N, Joseph C, Wei Y, Horwitz MS, Jacobson JS, et al.
Wang XJ, Tang T, Farid M, Quek R, Tao M, Lim ST, et al.
Boxer LA.
neutropenia is a condition when you have unusually low number of cells called neutrophils, which help fight bacteria and other organisms when they invade your body. D'Souza A, Jaiyesimi I, Trainor L, Venuturumili P. Granulocyte colony-stimulating factor administration: adverse events. [Guideline] Aapro MS, Bohlius J, Cameron DA, Dal Lago L, Donnelly JP, Kearney N, et al.
Medially, the 3.18-kg (7-lb) spleen crosses the midline. This website also contains material copyrighted by 3rd parties. Drug-induced agranulocytosis is a rare, potentially fatal idiosyncratic reaction that can occur unpredictably with a wide variety of drugs when taken in a conventional dose. The reported drugs were used alone, in combination with another drug known to be potentially toxic, or with another drug without known toxicity.
Any chemical or drug that can depress the bone marrow and cause hypoplasia or aplasia is capable of causing agranulocytosis.
We do not consider the dose-related granulocytopenia that commonly …
Carlsson G, Aprikyan AA, Ericson KG, Stein S, Makaryan V, Dale DC, et al.
Immune neutropenias.
Other drugs may have a combination of immune and nonimmune mechanisms or may have unknown mechanisms of action.Antimicrobials include penicillin, cephalosporins, vancomycin, chloramphenicol, gentamicin, clindamycin, doxycycline, flucytosine, nitrofurantoin, novobiocin, minocycline, griseofulvin, lincomycin, metronidazole, rifampin, isoniazid, streptomycin, thiacetazone, mebendazole, pyrimethamine, levamisole, ristocetin, sulfonamides, chloroquine, hydroxychloroquine, quinacrine, ethambutol, dapsone, ciprofloxacin, trimethoprim, imipenem/cilastatin, zidovudine, fludarabine, acyclovir, and terbinafine.Analgesics and anti-inflammatory agents include aminopyrine, dipyrone, indomethacin, ibuprofen, acetylsalicylic acid, diflunisal, sulindac, tolmetin, benoxaprofen, barbiturates, mesalazine, and quinine.Antipsychotics, antidepressants, and neuropharmacologic agents include phenothiazines (chlorpromazine, methylpromazine, mepazine, promazine, thioridazine, prochlorperazine, trifluoperazine, trimeprazine), clozapine, risperidone, imipramine, desipramine, diazepam, chlordiazepoxide, amoxapine, meprobamate, thiothixene, and haloperidol.Anticonvulsants include valproic acid, phenytoin, trimethadione, mephenytoin (Mesantoin), ethosuximide, and carbamazepine.Antithyroid drugs include thiouracil, propylthiouracil, methimazole, carbimazole, potassium perchlorate, and thiocyanate.Cardiovascular drugs include procainamide, captopril, aprindine, propranolol, hydralazine, methyldopa, quinidine, diazoxide, nifedipine, propafenone, ticlopidine, and vesnarinone.Antihistamines include cimetidine, ranitidine, tripelennamine (Pyribenzamine), methaphenilene, thenalidine, brompheniramine, and mianserin.Diuretics include acetazolamide, bumetanide, chlorothiazide, hydrochlorothiazide, chlorthalidone, methazolamide, and spironolactone.Hypoglycemic agents include chlorpropamide and tolbutamide.Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine.Miscellaneous drugs include allopurinol, colchicine, aminoglutethimide, famotidine, bezafibrate, flutamide, tamoxifen, penicillamine, retinoic acid, metoclopramide, phenindione, dinitrophenol, ethacrynic acid, dichlorodiphenyltrichloroethane (DDT), cinchophen, antimony, pyrithyldione, rauwolfia, ethanol, chlorpropamide, tolbutamide, thiazides, spironolactone, methazolamide, acetazolamide, IVIG, and levodopa.Exposure to drugs or chemicals is the most common cause of agranulocytosis: about one half of patients have a history of medication or chemical exposure.
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