Use enough to cover the entire affected area.The contents of EVOCLIN Foam are flammable; avoid fire, flame and/or smoking during and immediately following application.White to off-white thermolabile foam. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.Abdominal pain and gastrointestinal disturbances, as well as gram-negative folliculitis, have also been reported in association with the use of topical formulations of clindamycin. If contact occurs, rinse eyes thoroughly with water.EVOCLIN Foam should be prescribed with caution in atopic individuals.Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.A total of 439 subjects with mild to moderate acne vulgaris were treated once daily for 12 weeks with EVOCLIN Foam.The incidence of adverse reactions occurring in ≥1% of the subjects in clinical trials comparing EVOCLIN Foam, and its vehicle is presented in Table 1.In a contact sensitization study, none of the 203 subjects developed evidence of allergic contact sensitization to EVOCLIN Foam.The following adverse reactions have been identified during post approval use of EVOCLIN Foam: application site pain, application site erythema, diarrhea, urticaria, abdominal pain, hypersensitivity, rash, abdominal discomfort, nausea, seborrhea, application site rash, dizziness, and pain of skin. Orally and parenterally administered clindamycin have been associated with severe colitis, which may end fatally.
Do not expose to heat or store at temperature above 120°F (49°C).EVOCLIN Foam may cause irritation such as erythema, scaling, itching, burning, or stinging.In the event a patient treated with EVOCLIN Foam experiences severe diarrhea or gastrointestinal discomfort, EVOCLIN Foam should be discontinued and a physician should be contacted.Read the Patient Information that comes with EVOCLIN Foam before you start using it and each time you get a refill. If contact occurs, rinse thoroughly with water.EVOCLIN Foam should be prescribed with caution in atopic individuals.Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.A total of 439 subjects with mild to moderate acne vulgaris were treated once daily for 12 weeks with EVOCLIN Foam.The incidence of adverse reactions occurring in ≥ 1% of the subjects in clinical trials comparing EVOCLIN Foam and its vehicle is presented in Table 1.In a contact sensitization study, none of the 203 subjects developed evidence of allergic contact sensitization to EVOCLIN Foam.The following adverse reactions have been identified during post approval use of EVOCLIN Foam: application site pain, application site erythema, diarrhea, urticaria, abdominal pain, hypersensitivity, rash, abdominal discomfort, nausea, seborrhea, application site rash, dizziness, pain of skin, colitis (including pseudomembranous colitis), and hemorrhagic diarrhea. Do not use EVOCLIN Foam in your eyes, mouth or vagina.What should I tell my doctor before using EVOCLIN Foam?Before you use EVOCLIN Foam, tell your doctor if you:EVOCLIN Foam can cause serious side effects including:Keep EVOCLIN Foam and all medicines out of the reach of children.General information about the safe and effective use of EVOCLIN Foam:FOR TOPICAL USE ONLY.
Use enough to cover the entire affected area. Do not use EVOCLIN Foam for a condition for which it was not prescribed. [Severe colitis has occurred following oral or parenteral administration of clindamycin with an onset of up to several weeks following cessation of therapy. Is Evoclin helpful for Folliculitis? Evoclin is mentioned in 22 posts about Folliculitis. 7.1 Erythromycin. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7 (S)-chloro-substitution of the 7 (R)-hydroxyl group of the parent antibiotic, lincomycin. 2 DOSAGE AND ADMINISTRATION. No significant increase in tumors was noted in the treated animals.A 1.2% clindamycin phosphate gel similar to EVOCLIN Foam caused a statistically significant shortening of the median time to tumor onset in a study in hairless mice in which tumors were induced by exposure to simulated sunlight.Genotoxicity tests performed included a rat micronucleus test and an Ames Salmonella reversion test.
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