If a person has a moderate to severe case of lithium-induced diabetes insipidus, the medication may need to be stopped. In patients treated long term it appears to be only partly reversible upon lithium discontinuation. doi: 10.1503/jpn.110186. A third potentially useful agent … of drug-induced diabetes insipidus. COVID-19 is an emerging, rapidly evolving situation. Clipboard, Search History, and several other advanced features are temporarily unavailable. Which drugs can induce diabetes?
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Treatment is symptomatic in most patients and the offending drug should be stopped. The authors report a case of diabetes insipidus (DI) associated with a ketamine infusion. Frequent monitoring will also be added to a treatment plan if diabetes insipidus is suspected of developing because of the medications that are being taken.There may be times when the benefits of the medication may be deemed to be better than the side effects of DI. Patients with diabetes insipidus may be successfully controlled with drugs other than vasopressin. … Prevention of lithium-induced nephrogenic diabetes insipidus is an important aspect of the treatment of affective disorders.
Close monitoring of the treatment aiming at 12-hour trough value of 0.4 to 0.6 mmol/L is recommended. A search of the World Health Organization's adverse effect database revealed 359 reports of drug-induced diabetes insipidus. doi: 10.2165/00002018-199921060-00002. Development of diabetes was evaluated over the following 4 years.
Some features of the site may not work correctly.Drug-induced diabetes insipidus is always of the nephrogenic type, i.e. Singer I, Forrest JN Jr. PMID: 181631 [Indexed for MEDLINE] Publication Types: Research Support, U.S. Gov't, P.H.S. Talk with your medical provider about DI and your treatment plan regarding any concerns you may have regarding this condition. unre-sponsiveness of the kidneys to the action of antidiuretic hormone. This condition is easily diagnosed by measuring urinary concentrating capacity during a thirst test (e.g. Arginine Vasopressin/adverse effects; Arginine Vasopressin/analogs & derivatives; Colchicine/adverse effects; Cyclic AMP/metabolism; Cyclophosphamide/adverse effects; … By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Patients with psychogenic polydipsia will concentrate their urine further and may develop hyponatremia during this treatment. Still other agents, such as the anesthetic methoxyflurane, have had their toxicity recognized almost immediately after their introduction [3, 4]. This condition is easily diagnosed by measuring urinary concentrating capacity during a thirst test (e.g. 2014 Dec;63(7):803-6. doi: 10.7727/wimj.2013.192. Diabetes insipidus is often characterized by excessive thirst and excessive urination.
Several drugs, such as lithium, had been in use for many years without recognition of these toxic side effects, although clinical symptoms appear in almost one out of every ten patients treated with lithium for manic-depressive disorders [1], Other … 12 hours of water deprivation) or by administration of a modified anti-diuretic hormone, desmopressin, to demonstrate the renal unresponsiveness. Endocr Pract . Published by Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. central diabetes insipidus: clinical characteristics and long-term course in a large cohort of adults. Drug-induced nephrogenic diabetes insipidus caused by other drugs usually occurs in critically ill patients in intensive care units receiving a multitude of drugs dominated by antimicrobials and cytostatics. 15 Approximately 0.2% of the patients in the control group developed diabetes compared to 1.1% of the patients in the atypical antipsychotic group.
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