Get information and tips on how to help you choose the right place to deliver your baby. Subscribe to MedHelp's free newsletter for Community Support, Experience, and Guidance. The total duration of breastfeeding was not stated, but the infant had developed normally at 20 months of age. Kim KS, Pae CU, Chae JH, et al. Weiden PJ, Daniel DG, Simpson G, et al. Dosages and corresponding milk olanzapine levels were as follows: 0.18 mg/kg daily with a level of 30 mcg/L on day 11 postpartum; 0.26 mg/kg daily with a milk levels of 35 mcg/L on day 10 postpartum; and 0.26 mg/kg daily with 8 milk levels were taken at 2 weeks postpartum. What was your side effects? J Clin Psychopharmacol 2004;24:93-5. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease; or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action.
She then breastfed her infants until 11 pm. [5]A 5-month-old infant was breastfed (extent not stated) by a mother who had been taking olanzapine 5 mg 3 times daily for 11 days. Another woman who took olanzapine throughout pregnancy was taking olanzapine 0.17 mg/kg daily while she partially breastfed her infant. No adverse health or developmental effects were noted during the observation period of 5 days to 8 weeks. At 8 months of age, the serum concentration was 0.02 mcg/L with a maternal dose of 5 mg daily. The duration of exposure to olanzapine was reported in 30 nursing mothers with a median of 30 days and mean of 74 days. [17]Unlike the phenothiazines, olanzapine has a minimal effect on serum prolactin levels. Using these data, an exclusively breastfed infant would consume an average of 1.6% of the maternal weight-adjusted dosage (range 0 to 2.66%). Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants. Four plasma samples were obtained at 6 weeks and 7 months postpartum. For schizophrenia, it can be used for both new onset disease and long-term maintenance. Flovent HFA and Flovent Diskus are both Pregnancy Category C drugs, meaning that animal studies have shown a potential for fetal harm, but well-controlled studies in humans are not available. Follow-up of the breastfed infant for 11 months found no adverse effects and normal development of the infant. A fifth had a somewhat decreased intellectual development on testing, but her mother had also taken clonazepam, droperidol, sertraline, thioridazine and valproic acid while breastfeeding. Var L, Ince I, Topuzoglu A, et al. [4]Seven mother-infant pairs were studied during maternal olanzapine use. After 7 days of therapy, milk samples were obtained at 4 am, 8 am and 11 pm for 27 of the next 45 days. The median infant dosage was 1.12% (range 0.22 to 1.19%) of the maternal weight-adjusted dosage in 6 of the mothers and 1.13% in the seventh. Kinon BJ, Ahl J, Liu-Seifert H, et al. I got prescribed flovent for my asthma. [9]A woman with psychosis began treatment with long-acting olanzapine injection during pregnancy. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. My doctors switched my meds when I got pregnant to reduce risks for me and the baby. I am not on flovent, but I am on asthmanex to control my asthma and proair for attacks. Another woman who took olanzapine throughout pregnancy was taking olanzapine 0.17 mg/kg daily while she partially breastfed her infant.
[1,2] Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.Nine paired serum and milk levels were obtained from 5 mothers who were taking olanzapine. Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone. [11]In one 4-month-old infant, olanzapine was undetectable (<1 mcg/L) in serum 15 hours after the mother's dose (dose unstated). Flovent … [16] The same author reported 5 infants who were breastfed (extent not stated) during postpartum maternal treatment for bipolar disorder. Levels ranged from 11 mcg/L at 23 hours after a dose to 21 mcg/L at 9 hours after the following dose. The mean dose was 7.5 mg daily (range 5 to 20 mg daily) and serum levels were at steady state. Maguire GA. Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences. Four milk samples were obtained at 6 weeks and 7 months postpartum.
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