Unable to load your delegates due to an error Clipboard, Search History, and several other advanced features are temporarily unavailable. The post‐transplant course was stable with good renal function (Appendix C‐reactive protein: 12.29 mg/L Others normal (including white blood cell count, galactomannan, procalcitonin and (1,3)‐β‐D‐glucan)Tacrolimus and fluconazole have been reported to interact in a disparate manner in transplantation recipients. Any queries (other than missing content) should be directed to the corresponding author for the article.Please check your email for instructions on resetting your password. Surgery was uneventful. Low‐dose oral fluconazole was effective antifungal prophylaxis, but had no significant effect on tacrolimus trough levels or overall exposures.It would be clinically useful to know how tacrolimus dosages were affected by the start or discontinuation of fluconazole therapy.
Tell your doctor about all your current medicines and any medicine you start or stop using. Drug-drug interactions tool . They go together like Chinese food and chocolate pudding. Binding of fluconazole and other azoles in rat liverGreater impact of oral fluconazole on drug interaction with intravenous calcineurin inhibitors as compared with intravenous fluconazoleInteraction between azole antifugals drugs and tacrolimus in four kidney transplant patientsEvaluation of the drug interaction between intravenous high‐dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patientsLow‐dose fluconazole prophylaxis in kidney transplant recipients receiving tacrolimusEffects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipientsFluconazole therapy in transplant recipients receiving FK506Prograf® (tacrolimus) U.S. Food and Drug Administration drug label, revised June 2019Clinical pharmacogenetics implementation consortium (CPIC) guidelines for CYP3A5 genotype and tacrolimus dosingPharmacokinetics, pharmacodynamics and pharmacogenetics of tacrolimus in kidney transplantationPharmacokinetic study of the combination of tacrolimus and fluconazole in renal transplant patientsTacrolimus trough level adjustment after administration of fluconazole to kidney recipientsEffect of fluconazole on blood levels of tacrolimusInterpretation and Understanding of Clinical Drug Interactions Between Azoles and Immunosuppressants in Solid Organ Transplant Recipients,
Please enable it to take advantage of the complete set of features! The information provided here is for informational purposes only. Drug interactions of clinical significanceManagement of drug and food interactions with azole antifungal agents in transplant recipientsClinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of AmericaEffect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitroCYP3A5 polymorphisms in renal transplant recipients: influence on tacrolimus treatmentEffect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomesInhibitory potential of antifungal drugs on ATP‐binding cassette transporters P‐glycoprotein, MRP1 to MRP5, BCRP, and BSEPPotential impact of cytochrome P450 3A5 in human liver on drug interactions with triazolesEffect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomesSolitary inhibition of the breast cancer resistance protein efflux transporter results in a clinically significant drug‐drug interaction with rosuvastatin by causing up to a 2‐fold increase in statin exposureDisposition of azole antifungal agents.
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