When taken together with ACE inhibitors or potassium salts there is an increased risk of hyperkalemia.
Trade Names: Aldactone® General Description: Spironolactone is a diuretic used in dogs and cats to remove excess fluid from the body. This means that you'll have to
Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. emergency center if you're concerned about his health at all.
nonetheless not approved by the FDA for use in dogs. The drug is administered in also possible that your pet may have an extreme allergic reaction to Spironolactone. Spironolactone is a synthetic 17-lactone drug and competitive aldosterone receptor (mineralocorticoid receptor) blocker (MRB).
Clinical trials are currently evaluating the effects of spironolactone in combination with an ACEI in the treatment of dogs with stage B2 and C MMVD.There are currently no consensus statements regarding the use of spironolactone in other diseases, such as DCM, heartworm disease, and congenital heart disease. 6 Urinary potassium excretion, however, did decrease significantly at dosages of 1 and 2 mg/kg. this medicine as well, so it's crucial that you watch him after Unlike other diuretics, spironolactone does not cause blood potassium to be lost. Dogs with myxomatous mitral valve disease treated with spironolactone remained in the study for a significantly longer time period. pet's kidneys and other organs, but it can become dangerous if there is Licensed in dogs for the treatment of congestive heart failure Heart: congestive heart failure caused by mitral valve disease Heart: mitral valve degenerative disease. Interaction. Indications. kidneys while it helps to flush out excess potassium. Logic supports spironolactone’s utility and its history, along with research data, support its safety.The role of spironolactone in the treatment of heart failure due to ventricular diastolic dysfunction and preserved systolic function (heart failure with preserved ejection fraction [HFpEF]) is an area of ongoing research.The association between hyperaldosteronism and development of myocardial fibrosis in human and experimental animal models of hypertension is well established.However, in a recently completed large study in humans with HFpEF, the addition of spironolactone to existing heart failure therapy did not result in a significant survival benefit or reduction in hospitalization for heart failure, although there were substantial geographic differences in patient response.Hyperaldosteronism and activation of the RAAS, in particular, are implicated in the pathologic ventricular remodeling and diastolic myocardial dysfunction in hypertrophic cardiomyopathy (HCM) in humans.Aldosterone is elevated in Maine coon cats with asymptomatic HCM,A double-blinded, placebo-controlled clinical trial has evaluated the use of spironolactone (1.7–3.3 mg/kg PO Q 24 H) in cats with heart failure due to cardiomyopathy (the majority of cats had HCM).The positive results from studies of MRBs in patients with heart failure and low ejection fraction support the existence of aldosterone breakthrough (ABT): the phenomenon in which RAAS blockade with an ACEI—with or without an angiotensin-receptor blocker (ARB)—is incomplete and aldosterone levels rise despite RAAS suppressive therapy.Monitoring the UAldo:C ratio may, therefore, help optimize an individual patient’s pharmacotherapy and determine whether spironolactone should be added as an adjunctive therapy to improve RAAS blockade.Based on clinical and research data, we use spironolactone in almost all instances in which ACEIs are used, which includes dogs with the following:Although preliminary data are promising, we do not feel there is yet adequate evidence for routine use of spironolactone in cats.ABT = aldosterone breakthrough; ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin-receptor blocker; CHF = congestive heart failure; DCM = dilated cardiomyopathy; HCM = hypertrophic cardiomyopathy; HFpEF = heart failure with preserved ejection fraction; MMVD = myxomatous mitral valve disease; MR = mineralocorticoid receptor; MRB = mineralocorticoid receptor blocker; RAAS = renin–angiotensin–aldosterone system; UAldo:C = urine aldosterone-to-creatininea.
Of 212 dogs, 102 were treated with spironolactone in addition to standard therapy and 110 were treated with standard therapy alone. It is used with furosemide, digoxin, and ACE 1 inhibitors in dogs with chronic congestive heart failure. Dosing Information of Spironolactone for Dogs and Cats; Medication should never be administered without first consulting your veterinarian. Therefore, the primary rationale for adding spironolactone as adjunctive therapy for heart failure is now MR (specifically, aldosterone) blockade.Spironolactone and another synthetic MRB, eplerenone, have recently been evaluated in humans with mild to severe heart failure and low ejection fraction.These studies showed a significant benefit when additional blockade of the RAAS—in the form of MR blockade—was added to preexisting RAAS blockade with an ACEI.
This medicine works to increase the volume of urine that your pet produces, which in turn helps to flush out his system. An earlier study found that spironolactone had no effect on urinary sodium and water excretion in normal dogs when it was administered at dosages of 1, 2, 4, and 8 mg/kg PO Q 24 H for 8 days. tablet form; most owners will mix the tablets in with food or give them signs as well.
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