Hyperpyretic crises or severe convulsive seizures may occur in patients receiving such combinations. If you are a consumer or patient please visit
Dosage should be initiated at a low level and increased gradually, noting carefully the clinical response and any evidence of intolerance. There are case reports of patients succumbing to fatal dysrhythmias late after overdose: these patients had clinical evidence of significant poisoning prior to death and most received inadequate gastrointestinal decontamination. Initial dosage should be low and increases should be gradual and cautiously prescribed.The drug is contraindicated during the acute recovery period after a myocardial infarction. The clinical effect is hypothesized as being due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings. Use this medication regularly in order to get the most benefit from it. Updated The complete text of the Medication Guide is reprinted at the end of this document.Patients should be advised of the following issues and asked to alert their prescriber if these occur while taking imipramine hydrochloride.Patients should be advised that taking imipramine hydrochloride can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle-closure glaucoma. Furthermore, whenever one of these other drugs is withdrawn from co-therapy, an increased dose of tricyclic antidepressant may be required. An acute overdose of any amount in infants or young children, especially, must be considered serious and potentially fatal.These may vary in severity depending upon factors such as the amount of drug absorbed, the age of the patient, and the interval between drug ingestion and the start of treatment. Use Older adults may be more sensitive to the side effects of this drug, especially dizziness (more likely when standing up), drowsiness, Caution is advised when using this drug in children. a b f Uses for Imipramine Hydrochloride Major Depressive Disorder. 6 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, and titanium dioxide.Imipramine HCl tablets, 50 mg contain the following inactive ingredients: colloidal silicon dioxide, D & C yellow No. Talk with the doctor if this medication stops working well.Inform your doctor if your condition persists or worsens.Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (e.g., confusion, Tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e.g., fever, persistent This medication may increase serotonin and rarely cause a very serious condition called Get medical help right away if you have any very serious side effects, including: This is not a complete list of possible side effects. If it is near the time of the next dose, skip the missed dose. This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. Imipramine toxicity: The toxic reaction of the body to the substance, possibly via allergic reaction or overdose. 53489-332-07 Before using this medicine, consult your doctor or pharmacist if you have had: a recent Before using this medication, tell your doctor or pharmacist your medical history, especially of: The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Do not take more or less medication or take it more frequently than prescribed. An individual who is stable on a given dose of TCA may become abruptly toxic when given one of these inhibiting drugs as concomitant therapy. 53489-330-01, Some people may have a particularly high risk of having suicidal thoughts or actions.How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you:What else do I need to know about antidepressant medicines?Never stop an antidepressant medicine without first talking to a healthcare provider.Antidepressants are medicines used to treat depression and other illnesses.Antidepressant medicines can interact with other medicines.Not all antidepressant medicines prescribed for children are FDA approved for use in children.
53489-331-07, Imipramine hydrochloride is not approved for use in pediatric patients (Drug-Placebo Difference in Number of Cases of Suicidality per 1000 Patients TreatedAll patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases.Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to health care providers.
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