Putting on pounds was, and to some extent remains, a welcome indicator of the effectiveness of medication and a reassuring sign of a return to health.However, once potent therapies came along to stomp viral replication and stop opportunistic conditions, obesity replaced wasting as the major body issue for people living with HIV. For immediate assistance, contact Customer Service: Over 21,800 individuals in the U.S. and Canada who started HIV therapy between 2007 to 2015 -- almost 4,100 of whom began with an integrase inhibitor in the mix (51% RAL, 37% elvitegravir [EVG], and 12% DTG) -- were included in Those initiating with a non-nucleoside saw a median 4.1 kg gain over the first five years of treatment, compared with 5.0 kg with a protease inhibitor and 5.8 kg with an integrase inhibitor. Besides being unwelcomed by many patients, excess weight carries health risks. We studied pharmacogenetics of weight gain following switch from efavirenz (EFV)- to INI-based ART. One of the first is Studies of treatment-naive antiretroviral initiators provide a more level playing field to assess differential effects on weight.
At the 2018 International Workshop on Comorbidities and Adverse Drug Reactions in HIV, the NA-ACCORD cohort "weighed" in. to maintaining your privacy and will not share your personal information without greater weight gain among treatment-naive persons starting integrase inhibitors Abstract Body Obesity among persons living with HIV (PLWH) has steadily increased in the era of combination antiretroviral therapy (ART), and some PLWH experience substantial weight gain after initiating ART that may lead to metabolic comorbidities and poorer survival. But they are not without their downsides.Neuro-psych effects are rare, but appear to be a family curse. In models predicting changes in weight over time, integrase inhibitors were projected to produce the greatest increase in weight, with DTG having a greater effect than other drugs of this class. Linked to diabetes mellitus, cardiovascular disease, and even frailty, excessive weight in people living with HIV has become a target for intervention.
For more information, please refer to our Privacy Policy. Databases need to be dusted off, and those carefully conducted weights obtained at study visits compared across treatment arms. Wolters Kluwer Health Switching from a regimen that has food restrictions to one that does not could, conceivably, have an impact on caloric intake and, therefore, weight. Please try after some time.Get new journal Tables of Contents sent right to your email inbox Integrase inhibitors have revolutionized HIV treatment, as a glance at HIV treatment guidelines over the past few years makes clear. Patients at an HIV clinic in the southeastern USA were on EFV-based ART for at least 2 years and with no viral… Weight gain on integrase inhibitor treatment was first flagged up in late 2018 and, since the first reports, other research groups have been looking at weight gain in a wider range of patient groups. The purpose of this review was to seek answers regarding neuropsychiatric adverse reactions, as well as weight gain, because these are the 2 most common categories of adverse reactions established in preivous studies. Message:
Brief Report: Weight Gain in Persons With HIV Switched From Efavirenz-Based to Integrase Strand Transfer Inhibitor-Based Regimens J Acquir Immune Defic Syndr. Dolutegravir is related to the heaviest burden in terms of neuropsychiatric side effects.
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