The mean elimination plasma half-life of mefloquine is between two and four weeks.
Subjects in the chloroquine arm received chloroquine diphosphate (150-mg base; Resochin [P. T. Bayer Indonesia]) in 3 doses over 48 h: 10 mg base/kg on day 0, 10 mg base/kg on day 1, and 5 mg base/kg on day 2. Search for other works by this author on: During long-term use, the plasma half-life remains unchanged.Liver function tests should be performed during long-term administration of mefloquine.Specifically it is used as mefloquine hydrochloride. Total clearance is through the liver, and the primary means of excretion is through the bile and feces, as opposed to only 4% to 9% excreted through the urine. Its elimination in persons with impaired liver function may be prolonged, resulting in higher plasma levels and an increased risk of adverse reactions.
Mefloquine (WR 142,490) in the treatment of human malariaTrials of mefloquine in vivax and of mefloquine plus `Fansidar' in falciparum malariaA clinical trial of mefloquine in the treatment of A comparative clinical study of mefloquine and chloroquine in the treatment of vivax malariaTherapeutic responses to different antimalarial drugs in vivax malariaVivax malaria resistant to treatment and prophylaxis with chloroquineChloroquine/doxycycline combination versus chloroquine alone, and doxycycline alone for the treatment of Malaria in a cohort of Javanese migrants to Indonesian PapuaAssessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malariaTherapeutic response to antimalarial and antibacterial drugs in vivax malariaShort report: therapeutic efficacy of chloroquine combined with primaquine against Monitoring antimalarial drug resistance, report of a WHO consultation Geneva, Switzerland, 3-5 December 2001Comparison of two mefloquine regimens for treatment of Gamma-globulin and acquired immunity to human malaria© 2006 by the Infectious Diseases Society of America In malaria, the role for immunity in clearing infection has been established [This report constitutes the first published evidence, to our knowledge, from a large-scale clinical trial of the efficacy of a standard 15 mg/kg dose of mefloquine against chloroquine-resistant We would like to express sincerest appreciation to Dr. Ingerani, Dr. A. Soemarjati, and Dr. Sri Astuti (National Institutes of Health Research and Development branches of the Indonesian Ministry of Health) and Dr. W. Kalalo and Dr. B. Subianto (Jayapura Provincial Health Service) for their kind support of this project.The assertions herein are the views of the authors and do not reflect official policy of the US Department of the Navy or the US Department of Defense.Present affiliation: Naval Medical Research Center Portsmouth, Portsmouth, Maryland.Oxford University Press is a department of the University of Oxford. chloroquine is only effective against malaria from certain areas of the world.
Lariam (mefloquine) is indicated for the treatment of mild to moderate acute malaria caused by mefloquine-susceptible strains of P. falciparum (both chloroquine-susceptible and resistant strains) or by Plasmodium vivax. 3.4 Mefloquine (5370) Mefloquine (3.1.27), sold under the brand name Lariam, is an orally administered very potent blood schizontocide that has been marketed since 1990 for both malaria prophylaxis and for acute treatment of falciparum malaria.It is a long-acting antimalarial drug known for its efficacy against chloroquine … Search for other works by this author on: Lausanne, Other / Non US It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwideFor full access to this pdf, sign in to an existing account, or purchase an annual subscription. Search for other works by this author on: Reprints or correspondence: Dr. Jason D. Maguire, Infectious Diseases Div., Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708-2197 ( The US Food and Drug Administration approves the use of mefloquine for treatment of mild-to-moderate acute malaria caused by mefloquine-susceptible strains of Plasmodium falciparum or by Plasmodium vivax [1].
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