An infusion pump or other such device and frequent monitoring of strength of contractions and fetal heart rate are necessary for the safe administration of Oxytocin for the induction or stimulation of labor. Maternal sinus bradycardia with abnormal atrioventricular rhythms has also been noted when Oxytocin was used concomitantly with cyclopropane anesthesia.There are no animal or human studies on the carcinogenicity and mutagenicity of this drug, nor is there any information on its effect on fertility.There are no known indications for use of Oxytocin in the first and second trimester of pregnancy other than in relation to spontaneous or induced abortion. doxazosin oral and nifedipine oral both increase anti-hypertensive channel blocking. MI 3. pregnancy 4. cerebrovascular accident 5. ischemic attack 6. The drug distributes throughout the extracellular fluid, with minimal amounts reaching the fetus. Each mL of Oxytocin Injection, USP (synthetic), intended for intravenous infusion or intramuscular injection, possesses an oxytocic activity equivalent to 10 USP Oxytocin Units and contains chlorobutanol anhydrous (chloral derivative) 0.5%. Contraindicated in patients with very low blood pressure or shock due to heart problems and hypersensitivity.
Because the mechanisms of action of these two agents are different, it is reasonable to suggest that they be used in combination to control premature labor. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Carboprost tromethamine (PGF2a analogue) 2. misoprostol (PGE1 analogue)1. bed rest 2. tocolytics 3. glucocorticoids (if < 34 wks)The 3 most common tocolytic agents for treatment of preterm labor1. doxazosin oral and nifedipine oral both increase blood pressure lowering effect. Oxytocin injection (synthetic) is a sterile, clear, colorless solution of Oxytocin in Water for Injection prepared by synthesis. It is indicated for (1) induction of labor in patients with a medical indication for the initiation of labor, such as Rh problems, maternal diabetes, pre-eclampsia at or near term, when delivery is in the best interest of mother and fetus or when membranes are prematurely ruptured and delivery is indicated; (2) stimulation or reinforcement of labor, as in selected cases of uterine inertia; (3) adjunctive therapy in the management of incomplete or inevitable abortion. excessive fluid retention or water intoxication -> 2. hyponatremia 3. heart failure 4. seizures 5. deathpartial agonist at alpha-adrenergic receptors and some serotonin receptorsActivation of alpha-adrenergic receptors during pregnancy leads toUterine sensitivity to stimulant effects of ergot alkaloids increases during pregnancy due to1. AVODART is contraindicated for use in pregnancy because it may cause harm to the male fetus [see CONTRAINDICATIONS].
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The information provided here is for informational purposes only. Contraction frequency (contractions per ten minutes) was not significantly affected. Nifedipine Dosage and administration ... Nifedipine Adult: 10 mg SL or buccal (puncture end of capsule with needle and squeeze or have patient bite and … Area under the curve decreased by 73.2% and frequency was reduced from 13 to 8 contractions.
The dose may be gradually increased in increments of no more than 1 to 2 mU/min., until a contraction pattern has been established which is similar to normal labor.The fetal heart rate, resting uterine tone, and the frequency, duration, and force of contractions should be monitored.The Oxytocin infusion should be discontinued immediately in the event of uterine hyperactivity or fetal distress. Select one or more newsletters to continue. Clipboard, Search History, and several other advanced features are temporarily unavailable. Oxytocin's plasma half-life is between 1 and 6 minutes. Interactions; More ; Warning Do not use Pitocin (oxytocin) to start the labor unless needed for medical reasons. Because many drugs are excreted in human milk, caution should be exercised when Oxytocin is administered to a nursing woman.The following adverse reactions have been reported in the mother:Excessive dosage or hypersensitivity to the drug may result in uterine hypertonicity, spasm, tetanic contraction or rupture of the uterus.The possibility of increased blood loss and afibrinogenemia should be kept in mind when administering the drug.Severe water intoxication with convulsions and coma has occurred, and is associated with a slow Oxytocin infusion over a 24-hour period. Talk with your doctor. The decision can only be made by carefully weighing the potential benefits which Oxytocin can provide in a given case against rare but definite potential for the drug to produce hypertonicity or tetanic spasm.Maternal deaths due to hypertensive episodes, subarachnoid hemorrhage, rupture of the uterus and fetal deaths due to various causes have been reported associated with the use of parenteral oxytocic drugs for induction of labor and for augmentation in the first and second stages of labor.Oxytocin has been shown to have an intrinsic antidiuretic effect, acting to increase water reabsorption from the glomerular filtrate.
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