The information It appears you don't have enough CME Hours to take this Post-Test. The adverse events reported are presented in Table S4 and are consistent with the summary of product characteristics as expected side effect profile for each drug.
Maternal and neonatal health resource use was similar between treatment groups (Table S3).A prespecified exploratory subgroup analysis of the impact of ethnicity on efficacy of each treatment did not show any significant difference in mean systolic or diastolic brachial BP in black women (systolic 0.5 mm Hg; −4 to 5 mm Hg; diastolic 0.1 mm Hg; −3 to 3 mm Hg). These activities will be marked as such and will provide links to the required software. The mean PCR after randomization was 11.5 mg/mmol (SD, 1.9) in the nifedipine group compared with 7.5 mg/mmol (SD, 1.8) in the labetalol group. Women with pre-eclampsia should be transferred to primary care only if: … Please sign up or log in to your ObGFirst to access this Premium Content OBG Project CME requires a modern web browser (Internet Explorer 10+, Mozilla Firefox, Apple Safari, Google Chrome, Microsoft Edge). Evidence from the Control of Hypertension in Pregnancy Study demonstrates maternal benefit of tight control of BP using antihypertensive agents in reducing the incidence of severe hypertension without an increase in adverse perinatal outcomes.Recruitment to randomized controlled trials of medication in pregnancy is challenging in view of the real and perceived risk of fetal harm. … Group means and treatment effects were calculated as geometric means and ratios of geometric means given that log transformations were used. Demonstrating feasibility is important given the costly nature of large multicenter studies and need for suitable pragmatic designs to ensure definitive studies will fully answer the research questions posed.Nifedipine was associated with reduced central aortic pressure and augmentation index (markers of arterial stiffness).
We confirmed the feasibility of conducting a randomized controlled trial investigating effectiveness of first-line antihypertensive agents for the treatment of chronic hypertension in pregnancy.
Neonatal unit admission was slightly lower in the labetalol group compared with the nifedipine group (22% versus 29%).
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Doctors give unbiased, trusted information on whether Labetalol can cause or treat Pregnancy: Dr. Klein on labetalol in pregnancy: Most pregnant women with chronic hypertension are on Labetalol (a combined Alpha and beta blocker) that is fairly effective and safe for that purpose. Tap the button to learn more about ObGFirstYou are now leaving the ObG website and on your way to PRIORITY at UCSF, an independent website.
More: Guidance. The analysis was repeated excluding the women who developed superimposed preeclampsia (labetalol n=35 versus nifedipine n=27) with minimal effect on the results; PCR increased by 43% (18%–74%), and the mean PCR after randomization was 11.5 mg/mmol (SD, 1.9) in the nifedipine group compared with 7.4 mg/mmol (SD, 1.9) in the labetalol group.There were 4 serious adverse events reported, all for unplanned hospital admissions not related to the pregnancy; 1 was in the labetalol arm (admission for epistaxis) and 3 in the nifedipine arm (1 case of gastroenteritis, 1 case of deep vein thrombosis, and 1 case of influenza). The statistical software Stata/SE version 14 for Windows was used for all analyses.
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