have demonstrated that a 10‐day levofloxacin‐based therapy (pantoprazole 40 mg, amoxicillin 1 g, levofloxacin 250 mg, all twice daily for 10 days) is more effective (ITT eradication rate of 70% vs. 37%) than 1‐week quadruple therapy for patients who had failed one or more H. pylori eradication regimens. Wei-Chen Tai and Chien-Hua Chiu are co-first authors.Copyright © 2013 Wei-Chen Tai et al.
Ten patients lost to follow-up in EAL-10 group and 7 in the EAL-14 group resulted in 90 in the PP study for EAL-10 and 93 for EAL-14 (Figure Eradication rates attained by EAL-10 and EAL-14 were 75.6%; 95% CI = 63.9–85.3% and 92.5%; 95% CI = 84.5–98.1%, The adverse events were 11% (11/100) in EAL-10 group and 16% (16/100) in EAL-14 group (Table Quinolone-containing triple therapy is one of the recommended second-line therapies after the failure of the standard first-line empirical clarithromycin-containing therapy, with bismuth-containing quadruple therapy as an alternate [Levofloxacin is a levorotatory isomer of ofloxacin with known activity against many Gram-negative and Gram-positive bacteria [Drug resistance to antibiotics is an important key factor in successful Another reason for the failure of quinolone-containing triple therapies as second-line eradication regimens is the duration of the treatment instead of the dosage.
Rescue Therapy for Ninety‐six percentage of patients in the LAL group and 94% of patients (two patient defaulted follow‐up) in the quadruple group had completed the study medications. Bilardi et al. Demographic data and endoscopic appearances of the two patient groups.The major outcomes of EAL-10 and EAL-14 eradication therapy.Univariate analysis of the clinical factors influencing the efficacy of Multivariate analysis of the clinical factors influencing the efficacy of Ten-Day versus 14-Day Levofloxacin-Containing Triple Therapy for Second-Line Anti-Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDivision of General Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
Usual Adult Dose for Sinusitis.
All patients provided their written informed consent before endoscopic interventions.The primary endpoint was the successful eradication of The rapid urease test involved the collection of gastric antrum biopsy specimens by endoscopy, which were tested using a urea agar base enriched with 40% urea solution (eUAB, Oxoid) and a commercial rapid urease test (Pronto Dry, Medical Instrument Corp, Switzerland) [The urea breath test was performed according to our previous studies [The primary outcome variables were the rates of eradication, the presence of adverse events, and the level of patient compliance.
Helicobacter pylori
Intervention: levofloxacin (500 mg b.i.d. and amoxicillin (1000 mg b.d.) Several recent studies suggest levofloxacin-based triple therapies as an alternative rescue treatment. Subjects, especially those with dual resistance to metronidazole and clarithromycin, may consider levofloxacin‐based therapy for levofloxacin‐sensitive strains.Levofloxacin, a laevorotatory isomer of ofloxacin, has shown an excellent activity against a variety of Gram‐positive and Gram‐negative organisms which are resistant to the established agents.Thus, the aims of this randomized‐controlled study were (i) to evaluate the efficacy of 1‐week lansoprazole, amoxicillin and levofloxacin triple therapy vs. standard quadruple therapy for the treatment of Consecutive patients presenting to Queen Mary Hospital, Hong Kong satisfying the following criteria were invited to participate in this study: age >18 years old, who had failed at least one course of During endoscopy, three antral biopsies and one corpus biopsy were taken. One antral biopsy was sent for Antral biopsy was collected during upper endoscopy and transported to the laboratory immediately.
Using the SPSS program (Statistical Package for the Social Sciences version 18, Chicago, IL, USA), the chi-square test with or without Yates’s correction for continuity and Fisher’s exact test were used to compare the major outcomes between groups. Review: Second-line rescue therapy of Helicobacter pylori
Infection in Year 2012 If you do not receive an email within 10 minutes, your email address may not be registered, Helicobacter pylori
Compliance and tolerance: compliance was determined through questioning and recovery of …
for 7 days.The proportion of patients having side‐effects and the mean duration of side‐effects were similar between the LAL arm and the quadruple group. There were 46 males (mean age 49 years) and 60 females (mean age 44 years). Helicobacter pylori Infection 2012 Helicobacter pylori , Efficacy of Two Levofloxacin‐Containing Second‐Line Therapies for elicobacter pylori: A Pilot Study, Comparison of 10 day bismuth quadruple therapy with high-dose metronidazole or levofloxacin for second-line Helicobacter pylori therapy: a randomized controlled trial, The most common side‐effects were dizziness and nausea/vomiting in the LAL group and nausea/vomiting and loose stool/diarrhoea in the quadruple group.
, III Conferencia Española de Consenso sobre la infección por Helicobacter pylori, Second-line Therapy With Levofloxacin After Failure of Treatment to Eradicate Helicobacter pylori Infection,
Ten-Day versus 14-Day Levofloxacin-Containing Triple Therapy for Second-Line Anti-
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