Medical monitoring of the patient is to be continued after emergency treatment.Loratadine, the active ingredient in Loratadine Tablets, is a tricyclic antihistamine with selective, peripheral HLoratadine has no clinically significant sedative or anticholinergic properties in the majority of the population and when used at the recommended dosage.During long-term treatment there were no clinically significant changes in vital signs, laboratory test values, physical examinations or electrocardiograms.Human histamine skin wheal studies following a single 10 mg dose has shown that the antihistamine effects are seen within 1-3 hours reaching a peak at 8-12 hours and lasting in excess of 24 hours. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.Dizziness, nausea and vomiting are the adverse effects most commonly seen with overdose. Concomitant ingestion of food can delay slightly the absorption of loratadine but without influencing the clinical effect. Loratadine is not removed by haemodialysis and it is not known if loratadine is removed by peritoneal dialysis. For Child 6 months–17 years. (See Section 4.4 Special warnings and Special precautions for use).Hepatic cholestatis, hepatic failure (including fatalities), hyperbilirubinaemia, jaundice.Alopecia, erythema multiforme, erythema nodosum, fixed drug eruption, hyperpigmentation of skin, photosensitivity, pruritis, rash, urticaria, vasculitis.Angioedema, exfoliative dermatitis, hyperpigmentation of nails, Stevens-Johnson Syndrome, toxic epidermal necrolysis.Drug rash with eosinophilia and systemic symptoms (DRESS)Arthritis, bone discolouration, cases of or exacerbation of systemic lupus erythematosus (SLE)(See Section 4.4 Special warnings and precautions for use), joint stiffness, joint swelling.Increased serum urea, acute renal failure, interstitial nephritis.General disorders and administration site conditions * Autoimmune hepatitis: See Section 4.4 Special warnings and precautions for useThe following syndromes have been reported. It also appears in tears and saliva.In contrast to most tetracyclines, minocycline appears to undergo some metabolism in the liver, mainly to 9-hydroxyminocycline. Increase in plasma concentrations of loratadine has been reported after concomitant use with ketoconazole, erythromycin, and cimetidine in controlled trials, but without clinically significant changes (including electrocardiographic).Interaction studies have only been performed in adults.A large amount of data on pregnant women (more than 1000 exposed outcomes) indicate no malformative nor foeto/ neonatal toxicity of loratadine.
With intravenous use. Normal doses of 200mg followed by 100mg every 12 hours produced plasma concentrations within the range of 1 … The generalised muddy-brown skin pigmentation may persist, particularly in areas exposed to the sun.
Contra-indications. As a precautionary measure, it is preferable to avoid the use of loratadine during pregnancy.Loratadine is excreted in breast milk, therefore the use of loratadine is not recommended in breast-feeding women.There is no data available on male and female fertility.In clinical trials that assessed driving ability, no impairment occurred in patients receiving loratadine. Enamel hypoplasia has also been reported.Tetracyclines have been found in the milk of lactating women who are taking a drug in this class.
Dosages should be maximally separated. Loratadine (Clarityn®) is a non-drowsy antihistamine used to treat allergies.
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