Continue typing to refine. Dosage in adults. In HIV-infected patients, the absolute bioavailability of a 750 mg single dose of atovaquone tablets taken with food is 23% with an inter-subject variability of about 45%. Taking a preventative medication like Maloff Protect is just one step towards optimised protection:Malaria is a tropical disease that is potentially very serious but preventable.
Oncogenicity studies on proguanil in combination with atovaquone have not been performed.This medicinal product does not require any special storage conditionsPVC/PVDC (clear) and hard tempered PVC/PVDC-Aluminium foil blisters containing 12 tablets.Building 2, 1st Floor, Croxley Park, Watford, WD18 8YATo bookmark a medicine you must sign up and log in.To view the changes to a medicine you must sign up and log in. • In patients who are taking rifampicin or rifabutin (see section 4.5) These events may have been seen at a lower frequency or not at all in clinical trials with atovaquone/proguanil.
If overdose occurs, the patient should be monitored and standard supportive treatment applied.Pharmacotherapeutic group: ANTIMALARIALS, Biguanides, Proguanil, combinations ATC Code: P01BB51 Maloff Protect is a fixed dose combination of atovaquone and proguanil hydrochloride which acts as a blood schizonticide and also has activity against hepatic schizonts of The constituents of Maloff Protect, atovaquone and proguanil hydrochloride, interfere with two different pathways involved in the biosynthesis of pyrimidines required for nucleic acid replication.
Atovaquone is highly protein bound (>99%) but does not displace other highly protein bound drugs Following oral administration, the volume of distribution of atovaquone in adults and children is approximately 8.8 L/kg. Pregnant women have an increased risk of developing severe malaria and a higher risk of fatality compared to non-pregnant women.The safety and effectiveness of Maloff Protect has not been established for chemoprophylaxis of malaria in patients who weigh less than 40 kg.Travellers should be reminded the need of receiving a full travel consultation if they have not already done so to undertake an overall risk assessment-based package of travel health advice. Official guidelines will normally include World Health Organisation (WHO) and public health authorities' guidelines.The daily dose should be taken with food or a milky drink (to ensure maximum absorption) at the same time each day.If patients are unable to tolerate food, Maloff Protect should be administered, but systemic exposure of atovaquone will be reduced. There are no other commonly used antimalarial drugs that offer a shorter period of medication. Taking a preventative medication like Maloff Protect is just one step towards optimised protection.Malaria can affect anyone, and some types of Malaria can take longer to develop. Observed from post-marketing spontaneous reports.
There are no studies in children with renal impairment.In patients with severe renal impairment, the elimination half lives (tIn adult patients with mild to moderate hepatic impairment there is no clinically significant change in exposure to atovaquone when compared to healthy patients. It is important that you keep up to date with the latest travel news and advice.When travelling to a malarial region of the world, you should take every step to avoid getting bitten by mosquitos. If you get any side effects, consult your doctor, nurse, or pharmacist. Don't miss out, mix & match across 100's of products. • continue for seven days after leaving the area. These positive effects with cycloguanil (a dihydrofolate antagonist) were significantly reduced or abolished with folinic acid supplementation. Oncogenicity studies on proguanil alone showed no evidence of carcinogenicity in rats and mice. Maloff Protect is available in pack sizes of 24 or 36 tablets.Maloff Protect is available in pack sizes of 24 or 36 tablets. Frequency taken from atovaquone label. The mechanism of action of atovaquone against Atovaquone is not cross-resistant with any other antimalarial drugs in current use.The antimalarial activity of proguanil is exerted via the primary metabolite cycloguanil (Atovaquone/proguanil acts as a blood schizonticide and also as activity against hepatic schizonts of There are no pharmacokinetic interactions between atovaquone and proguanil at the recommended dose.
Taking a preventative medication like Maloff Protect is just one step towards optimised protection.Malaria can affect anyone, and some types of Malaria can take longer to develop. Oncogenicity studies of atovaquone alone in mice showed an increased incidence of hepatocellular adenomas and carcinomas.
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