Basically it's a triptan drug that is used for vascular migraines. Plasma exposure (AUC) at the no-effect dose (2 mg/kg/day) for adverse effects on postnatal development was similar to that in humans at the MRHD.Oral administration of rizatriptan (0, 5, 100, or 250 mg/kg/day) throughout organogenesis and lactation resulted in neonatal mortality, reduced body weight (which persisted into adulthood), and impaired neurobehavioral function in offspring at all but the lowest dose tested. Made in Ireland.Each tablet contains 14.53 mg of rizatriptan benzoate, equivalent to 10 mg rizatriptan.Phenylketonurics: contains phenylalanine (a component of aspartame)Dist.
Maxalt should not be administered to patients with a history of stroke or transient ischemic attack Reports of transient and permanent blindness and significant partial vision loss have been reported with the use of 5-HTOveruse of acute migraine drugs (e.g., ergotamine, triptans, opioids, or a combination of drugs for 10 or more days per month) may lead to exacerbation of headache (medication overuse headache).
5-HTTriptan-naïve patients who have multiple cardiovascular risk factors (e.g., increased age, diabetes, hypertension, smoking, obesity, strong family history of CAD) should have a cardiovascular evaluation prior to receiving Maxalt. -Infant risk should be minimized by avoiding breastfeeding for 24 hours after administration of this drug. Rizatriptan is minimally bound (14%) to plasma proteins.The primary route of rizatriptan metabolism is via oxidative deamination by monoamine oxidase-A (MAO-A) to the indole acetic acid metabolite, which is not active at the 5-HTThe total radioactivity of the administered dose recovered over 120 hours in urine and feces was 82% and 12%, respectively, following a single 10-mg oral administration of The plasma half-life of rizatriptan in males and females averages 2-3 hours.Rizatriptan is not an inhibitor of the activities of human liver cytochrome P450 isoforms 3A4/5, 1A2, 2C9, 2C19, or 2E1; rizatriptan is a competitive inhibitor (KOral carcinogenicity studies of rizatriptan were conducted in mice (100 weeks) and rats (106 weeks) at doses of up to 125 mg/kg/day.
There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of Maxalt. Patients were instructed to treat a moderate to severe headache. Keep a list of them to show your doctor and pharmacist when you get a new medicine.Maxalt may cause dizziness, weakness, or fainting. The recommended starting dose of Maxalt is either 5 mg or 10 mg for the acute treatment of migraines in adults. Events are further classified within system organ class and enumerated in order of decreasing frequency using the following definitions: frequent adverse events are those occurring in (>)1/100 pediatric patients; infrequent adverse experiences are those occurring in 1/100 to 1/1000 pediatric patients; and rare adverse experiences are those occurring in fewer than 1/1000 patients.The following section enumerates potentially important adverse events that have occurred in clinical practice and which have been reported spontaneously to various surveillance systems. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for this drug and any potential adverse effects to the breastfed infant from the drug or from the underlying maternal condition.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.
Medication overuse headache may present as migraine-like daily headaches, or as a marked increase in frequency of migraine attacks. Because the reports include events observed in open studies, the role of Maxalt in their causation cannot be reliably determined. Made in Ireland.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
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