B. Oxytocin has specific receptors in the myometrium and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Intramuscular Administration: 1 mL (10 units) of oxytocin can be given after delivery of the placenta. Oxytocin Injection, USP (synthetic) is supplied as follows:We comply with the HONcode standard for trustworthy health information -
Add the container with dilute oxytocic solution to the system through the use of a constant infusion pump or other such device to control accurately the rate of infusion.The initial dose should be no more than 1 to 2 mU/min.
liver) 3000 mg/day (2000 mg/day for older adults/ pts w/ liver disease) The following dosage information is based upon the various regimens and indications in general use. This product may contain up to 12.5% decomposition products/impurities.
If uterine contractions become too powerful, the infusion can be abruptly stopped, and oxytocic stimulation of the uterine musculature will soon wane.An intravenous infusion of a non-Oxytocin containing solution should be started. Based on the wide experience with this drug and its chemical structure and pharmacological properties, it would not be expected to present a risk of fetal abnormalities when used as indicated.It is not known whether this drug is excreted in human milk. For Adult. Satin, MD," KennethJ. Results. By intravenous infusion. Other means of therapy, however, may be required in such cases.Oxytocin injection (synthetic) is indicated to produce uterine contractions during the third stage of labor and to control postpartum bleeding or hemorrhage.Oxytocin injection (synthetic) is contraindicated in any of the following conditions:Oxytocin injection (synthetic) when given for induction or stimulation of labor, must be administered only by the intravenous route and with adequate medical supervision in a hospital.All patients receiving intravenous Oxytocin must be under continuous observation by trained personnel with a thorough knowledge of the drug and qualified to identify complications. A physician qualified to manage any complications should be immediately available.When properly administered, Oxytocin should stimulate uterine contractions similar to those seen in normal labor.
Oxytocin Dosage and Administration. Objective To test the hypothesis that high-dose oxytocin, when used in a masked fashion, would result in shorter labors and less need for cesarean delivery.. Methods We conducted randomized, double-masked trials of high-dose compared with low-dose oxytocin for augmentation and induction of labor. Overstimulation of the uterus by improper administration can be hazardous to both mother and fetus. This assistance, known as We included nine randomised controlled trials involving 2391 women and their babies in this We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (31 August 2014) and the reference lists of relevant papers.We have included nine trials, involving 2391 women and their babies in this Results of primary outcomes revealed no significant differences in rates of vaginal delivery not achieved within 24 hours (Results of secondary outcomes revealed no difference between time from No other secondary outcomes were reported: unchanged/unfavourable cervix after 12 to 24 hours, meconium-stained liquor, neonatal Budden A, Chen LJY, Henry A. High-dose versus low-dose oxytocin infusion regimens for induction of labour at term. Methods: In this study, 108 women were randomly assigned to two groups of breast pump stimulation (n = 54) and oxytocin administration (n = 54). Dosage of Oxytocin is determined by uterine response. Control of Postpartum Uterine Bleeding. Available data and information are inadequate to define the benefits to risks considerations in the use of the drug product for elective induction. An infusion pump or other such device and frequent monitoring of strength of contractions and fetal heart rate are necessary for the safe administration of Oxytocin for the induction or stimulation of labor. Take this short survey so Cochrane can better meet your needs in the future. Even with proper administration and adequate supervision, hypertonic contractions can occur in patients whose uteri are hypersensitive to Oxytocin.Except in unusual circumstances, Oxytocin should not be administered in the following conditions: prematurity, borderline cephalopelvic disproportion, previous major surgery on the cervix or uterus including caesarean section, overdistention of the uterus, grand multiparity or invasive cervical carcinoma. Oxytocin injection (synthetic) is a sterile, clear, colorless solution of Oxytocin in Water for Injection prepared by synthesis. Cochrane Database of Systematic Reviews 2014, Issue 10. Some women do not begin labour spontaneously and may need assistance.
Consideration should, therefore, be given to the possibility of water intoxication, particularly when Oxytocin is administered continuously by infusion and the patient is receiving fluids by mouth.Severe hypertension has been reported when Oxytocin was given three to four hours following prophylactic administration of a vasoconstrictor in conjunction with caudal block anesthesia.
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