18(1):101Yalin OO, Uluduz D, Ozge A, Sungur MA, Selekler M, Siva A (2016) Phenotypic features of chronic migraine. Clin Neurol Neurosurg 112(6):463–466Mathew NT, Jaffri SF (2009) A double-blind comparison of onabotulinumtoxina (BOTOX) and topiramate (TOPAMAX) for the prophylactic treatment of chronic migraine: a pilot study. 14(1):71Benemei S, Fusi C, Trevisan G, Geppetti P (2014) The TRPA1 channel in migraine mechanism and treatment. 31(6):483–485Limmroth V, Biondi D, Pfeil J, Schwalen S (2007) Topiramate in patients with episodic migraine: reducing the risk for chronic forms of headache. Management includes identification and modification of exacerbating factors, treatment for acute migraine … Neurol Sci 38(Suppl 1):31–35Deen M, Correnti E, Kamm K, Kelderman T, Papetti L, Rubio-Beltran E et al (2017) Blocking CGRP in migraine patients - a review of pros and cons. Eli Lilly and Company. Proc Natl Acad Sci U S A 109(46):18985–18990Cernuda-Morollon E, Larrosa D, Ramon C, Vega J, Martinez-Camblor P, Pascual J (2013) Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine. You can also search for this author in Improved characterisation and diagnosis of its clinical features have led to the view of migraine as a complex, variable disorder of nervous system function rather than simply a vascular headache. Management includes identification and modification of exacerbating factors, treatment for acute migraine (commonly with triptans, NSAIDs, and antiemetic agents) early in an attack, and preventive therapy depending on migraine frequency and severity. (2018).
CNS Drugs. You can also search for this author in (2018). It is often described in the literature as the percentage of sufferers who are “headache free” at these two time points, however, studies also report the number of subjects who have a clinically meaningful reduction in their headache pain, which varies from a 30 to 50% decrease in headache pain intensity, depending on the authors. Modified with permission from Benemei, et al. J Headache Pain. Bigal ME, Serrano D, Reed M, Lipton RB (2008) Chronic migraine in the population burden, diagnosis, and satisfaction with treatment. Part of J Headache Pain. Improved prophylactic therapy is needed to reduce the high burden of chronic migraine in Italy. (2017). 18(1):96Israel H, Neeb L, Reuter U (2018) CGRP monoclonal antibodies for the preventative treatment of migraine. 17:26Bigal ME, Lipton RB (2006) Modifiable risk factors for migraine progression. These advances should prompt us to rethink the approach to this devastating disease and empower us to be vigilant and continue scientific clinical research, bearing in mind that only a common, shared clinical and scientific management strategy will improve CM ascertainment, distinguish phenotypes and biological markers, shed light on neglected clinical governance areas, provide customised healthcare and tailored therapy, optimise economic resources allocation and reduce the personal, social and economic burden of CM.
Br J Clin Pharmacol 80(2):193–199Bigal ME, Dodick DW, Rapoport AM, Silberstein SD, Ma Y, Yang R et al (2015) Safety, tolerability, and efficacy of TEV-48125 for preventive treatment of high-frequency episodic migraine: a multicentre, randomised, double-blind, placebo-controlled, phase 2b study. Migraine is a common neurological disorder characterized by recurrent headache episodes that accompany sensory-motor disturbances, such as higher sensitivity to touch and light, extremity heaviness or weakness, and speech or language disabilities. 3
43(4):336–342Buse D, Manack A, Serrano D, Turkel C, Lipton R (2010) Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. 29(12):1285–1293Katsarava Z, Mania M, Lampl C, Herberhold J, Steiner TJ (2018) Poor medical care for people with migraine in Europe - evidence from the Eurolight study. This review provides an update on prevailing concepts of migraine pathophysiology.Migraine is a common and debilitating neurological disorder experienced by approximately 10% of the global population.The various symptoms and neurological disturbances observed during all phases of migraine are complex and wide‐ranging. 54(6):987–995Martelletti P (2017) The application of CGRP(r) monoclonal antibodies in migraine spectrum: needs and priorities.
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