J Clin Gastroenterol. Objectives To describe the clinical, laboratory, and histological features in 3 cases of minocycline-related autoimmune hepatitis and to review the literature of similar cases in the adolescent population.. Design Case series.. He did not present to his doctor at this stage, but five months later, after the jaundice resolved, he became unwell again. Although he was still taking his minocycline at this stage, we do not know whether he took it continuously throughout. Setting Patients were cared for in the Division of … Following the first report of minocycline‐induced lupus (MIL) , several others have drawn attention to this association [8– 20]. More recently, minocycline has been associated with a number of autoimmune syndromes, of which hepatitis and a lupus‐like illness are the most common and can occur concurrently [5, 6]. Tetracyclines, including oral minocycline, have been associated with the development of autoimmune syndromes including a lupus-like syndrome manifested by arthralgia, myalgia, rash, and swelling. Design: Case series. COVID-19 is an emerging, rapidly evolving situation. 2018 Jan-Dec;10:1759091418801092. doi: 10.1177/1759091418801092.Case Rep Gastroenterol.
The fourth (case 4) was a 37 year old man who had also been taking long term minocycline for acne.
Epub 2018 Oct 10.Aljumah AA, Al Jarallah B, Albenmousa A, Al Khathlan A, Al Zanbagi A, Al Quaiz M, Al-Judaibi B, Nabrawi K, Al Hamoudi W, Alghamdi M, Fallatah H.Saudi J Gastroenterol.
Seven years later, nodules developed in all limb muscles.
A liver biopsy confirmed chronic active hepatitis. 2018 Oct;21(4):347-350. doi: 10.5223/pghn.2018.21.4.347. Three of these (cases 5, 6, and 7) were again young women taking minocycline who developed severe hepatitis and were positive for antinuclear antibody. Silverchair Information Systems 2018 Nov;24(7 Suppl):S1-S20. technical support for your product directly (links go to external sites):Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. 2013 Jul;7(3):869-75. doi: 10.1007/s12072-013-9448-x. Having determined that minocycline could cause an autoimmune drug reaction leading to hepatitis, we looked for further cases prospectively in 1993 and found four more (table 1, cases 4-7). We do not capture any email address. Minocycline is an antibiotic in the tetracycline family. Unable to load your collection due to an error The capsule and pellet-filled capsule is usually taken twice a day (every 12 hours) or four times a day (every 6 hours). These diseases include: eCollection 2018 May-Aug.Hepatol Int.
Monocycline is the most widely prescribed systemic antibiotic for acne largely because it needs to be given only once or twice a day and seems not to induce resistance. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!
The absence of eosinophils does not exclude the possibility of a minocycline cause. Although their acne deteriorated, all seven have … Subscribe and get access to all BMJ articles, and much more.You can download a PDF version for your personal record.If you are unable to import citations, please contact
Antibiotic therapy in autoimmune disorders Yossi Rosman1, Merav Lidar2,3,4 & Yehuda Shoenfeld*3,4 1Department of Medicine D, Sheba Medical Center, Tel Hashomer, Israel ... derivate – minocycline, indeed exerts substantial antirheumatic properties [20,21]. A 47-year-old female was diagnosed to have pulmonary, ocular, and nodular-type muscular sarcoidosis. In all, liver biopsies showed moderately severe changes of acute or chronic active hepatitis. 1999 Nov-Dec;16(6):469-72. doi: 10.1046/j.1525-1470.1999.00106.x.Hoefnagel JJ, van Leeuwen RL, Mattie H, Bastiaens MT.Pediatr Gastroenterol Hepatol Nutr. doi: 10.4103/sjg.SJG_159_18.ASN Neuro. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. 1998 Jul;27(1):74-5. doi: 10.1097/00004836-199807000-00016.Somech R, Arav-Boger R, Assia A, Spirer Z, Jurgenson U.Pediatr Dermatol. All seven patients' symptoms and laboratory investigations returned to normal within three months of their discontinuing minocycline.
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