Subcutaneous injection is contraindicated. In the event that vasopressors are considered for the management of severe hypotension which does not respond to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be considered. Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities. Leukopenia and agranulocytosis have been reported, usually when promethazine hydrochloride has been used in association with other known marrow-toxic agents.A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with promethazine hydrochloride alone or in combination with antipsychotic drugs. Dosage Form: injection Promethazine hydrochloride injection should not be given by the subcutaneous route because evidence of chemical irritation has been noted, and necrotic lesions have resulted following subcutaneous injection. When given concomitantly with promethazine hydrochloride injection, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Promethazine hydrochloride (10Each mL contains promethazine hydrochloride 25 mg, edetate disodium 0.1 mg, calcium chloride 0.04 mg, sodium metabisulfite 0.25 mg and phenol 5 mg in Water for Injection. This possibility should be considered with promethazine hydrochloride injection.The following laboratory tests may be affected in patients who are receiving therapy with promethazine hydrochloride injection:Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.An increase in blood glucose has been reported in patients receiving promethazine hydrochloride.Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine hydrochloride injection, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility. Convulsions may rarely occur. The average adult dose for amelioration of allergic reactions to blood or plasma is 25 mg.In hospitalized adult patients, nighttime sedation may be achieved by a dose of 25 to 50 mg of promethazine hydrochloride injection.For control of nausea and vomiting, the usual adult dose is 12.5 to 25 mg, not to be repeated more frequently than every four hours. When used for control of postoperative nausea and vomiting, the dosage of analgesics and barbiturates should be reduced accordingly (see Antiemetics should not be used in vomiting of unknown etiology in children and adolescents (see As an adjunct to preoperative or postoperative medication, 25 to 50 mg of promethazine hydrochloride injection in adults may be combined with appropriately reduced doses of analgesics and atropine-like drugs as desired. Promethazine is a competitive HPromethazine hydrochloride injection is indicated for the following conditions:Promethazine hydrochloride injection is contraindicated for use in pediatric patients less than two years of age due to the risk of respiratory depression Promethazine hydrochloride injection is contraindicated in comatose states.Under no circumstances should promethazine hydrochloride injection be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene (see Promethazine hydrochloride injection should not be given by the subcutaneous route because evidence of chemical irritation has been noted, and necrotic lesions have resulted following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection. pH 4.0 to 5.5; buffered with acetic acid-sodium acetate.Promethazine hydrochloride injection is a clear, colorless solution. Subcutaneous injection is contraindicated.
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Promethazine hydrochloride injection should be used with caution in pediatric patients 2 years of age and older (see Promethazine hydrochloride injection can cause severe chemical irritation and Drowsiness is the most prominent CNS effect of this drug.
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