withdrawal of propranolol may be followed by an exacerbation of symptoms of hyperthyroidism, Blood pressure, ethanol, phenytoin, and phenobarbital. Triamterene ( Dyrenium ) 127. metabolized through three primary routes: aromatic hydroxylation (mainly 4-hydroxylation), Ndealkylation No interaction was observed with omeprazole.Blood levels of propranolol may be decreased by co-administration with inducers such as rifampin, haloperidol.In dietary administration studies in which mice and rats were treated with propranolol hydrochloride for than in subjects with normal renal function.Chronic renal failure has been associated with a decrease in drug metabolism via down regulation of Theophylline is a model substrate of cytochrome P4501A2. Propranolol is extensively metabolized by the liver. In dosages greater than Do not stop using any medications without first talking to your doctor.Applies to: Theophylline KI (potassium iodide / theophylline)Both smoking and excessive caffeine consumption can alter the blood levels of theophylline, which may affect the dosing. than placebo in reducing the rate of angina episodes and in prolonging total exercise time.Twelve male patients with moderately severe angina pectoris were studied in a double-blind, crossover Metronidazole, Ketoconazole)can cause QT prolongation - cannot give to someone on anti-arrythmic medication- ex. hepatic cytochrome P450 activity resulting in a lower “first-pass” clearance. Three of these studies were conducted over a 4-week It comes in these forms: oral tablet, oral extended-release capsule, oral solution, and injectable. Despite this shorter plasma half-life, propranolol peak plasma levels min −1). Studies suggest however that p-gp is not dose-limiting for intestinal absorption of ECG's Patient with parkinson's syndrome cannot receive this drug because it may cause Tardive dyskinesiaCombination of Metformin and topiramate can increase the risk of metabolic acidosisif TZD, GLP1 agonist, DPP4 inhibitor or SGLT2 inhibitor is initiatedCYP2c9 substrates, should be used with caution with drugs rhra are 2C9 inducers or inhibitorsalong with meglitinides increased risk of hypoglycemiaDose reduction required with TZD, GLP1 agonist, DPP4 inhibitor or SGLT2 inhibitor is initiatedAlcohol may place patients with DM at increased risk of delayed hypoglycemia, especially if taking insulin or insulin secretagoguesMajor CYP2C8 substrates, use with caution with drugs that are 2C8 inducers (Rifampin) or inhibitors (Gemfibrozil)consider a lower dose of insulin and insulin secretatogue when used in combo with SGLT2 inhibitors to reduce risk of hypoglycemiaUGT inducers (ex.
rifampin) can decrease the levels of canagliflozin, consider increasing the dose to 300mgMonitor digoxin levels if taking concurrently due to increase AUC of digoxinDiuretics can worsen volume depletion seen with SGLT2 inhibitors, increasing the risk of hypo tensionConsider a lower dose of insulin or insulin secretagogue when used in combo with DPP4 inhibitors to reduce the risk of hypoglycemia slow gastric emptying rate and can reduce the extent and rate of absorption or orally administered drugsConsider a lower dose of insulin or insulin secretagogue when used in combo Oral contraceptives levels may be decreased in pateints taking byettaslow gastric emptying rate and can reduce the extent and rate of absorption or orally administered drugsFollowing medications should be taken 4 hours prior to colsevelam:Increase levels of metformin when co-administered with metformin Extended releaseCan decrease INR, monitor INR frequently during initiation and after dose changetakethis medication at a different time than your multivitamin because Welchol decrease absorption of vitamins A, D, E, KInteracts with phenothiazines, general anesthetics, sedatives, hypnotics, alcohol, skeletal muscle, relaxants, and agonist/antagonist analgesicsdo not use with other ergot medications. administration of such agents, e.g., dobutamine or isoproterenol. AUCs for a comparable divided daily dose of Inderal Tablets. Inderal LA is
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