The theoretical plasma trough target concentration was 0.44 mg/L.Plasma and CSF aciclovir concentrations in patients treated with iv aciclovir and/or oral valaciclovirNB.
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Antimicrobial Prescribing Guidelines . For Permissions, please e-mail: journals.permissions@oxfordjournals.org
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Physicians should perform reactive therapeutic drug monitoring to guide changes in anti–tumor necrosis factor (TNF) therapy in patients with active inflammatory bowel disease and should consider target trough concentrations of at least 5 mcg/mL for infliximab, at least 7.5 mcg/mL for adalimumab, and at least 20 mcg/mL for certolizumab pegol, according to a guideline from the AGA Institute, published in the September 2017 issue of Gastroenterology (Gastroenterology.
THERAPEUTIC DRUG MONITORING Therapeutic drug monitoring (TDM) is the use of drug concentration measurements in body fluids as an aid to the management of drug therapy for the cure, alleviation or prevention of disease. ... levels should be checked prior to each dose and the results should be discussed with a specialist familiar with therapeutic drug monitoring before the next dose is given; Vancomycin. Therapeutic Drug Monitoring (TDM): aciclovir and ganciclovir. Two children (patients 4 and 5) with suspected viral encephalitis were treated with iv aciclovir.
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heart rate, blood pressure), it is obviously better to adjust the dose on the basis of response.
Guidelines for Therapeutic Drug Monitoring of Cardio-vascular Drugs in order to ensure safe and effective phar-macotherapy for the treatment of cardiovascular diseases using appropriate TDM of blood drug concentrations. When peak concentrations were measured, CSF penetration was 9% on two occasions in patient 2 compared with trough CSF penetrations of 80% in the same patient (Table Oral valaciclovir was well tolerated in our very young children and can be considered for long-term treatment such as in relapsing HSV encephalitis or disease with focal destruction lesions on neuroimaging where prolonged iv aciclovir therapy is not practical and oral aciclovir has poorer bioavailability.
Scheffe, Nina; Schreiner, Rupert; Thomann, Anne; Findeisen, Peter Cattaneo, Dario; Gervasoni, Cristina; Vinti, Pietro; Cattaneo, Dario; Gervasoni, Cristina; Vinti, Pietro; Baldelli, Sara; Fusi, Marta; Zagato, Donatello; De Bona, Anna; Suardi, Elisa; Bossolasco, Simona; Ancona, Giuseppe; Rossotti, Roberto; Cernuschi, Massimo Zijp, Tanja R.; Toren-Wielema, Martha L.; Nannan Panday, Prashant V.; Zijp, Tanja R.; Toren-Wielema, Martha L.; Nannan Panday, Prashant V.; Kosterink, Jos G. W.; Berger, Stefan P.; Touw, Daan J.
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Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy.
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