Stat Med. L’olanzapine a des propriétés que n’ont pas d’autres neuroleptiques. Eur Neuropsychopharmacol.
Cette hyperactivité physique est liée en partie à la gravité de l’anorexie mentale (AM).
Gray matter in first-episode schizophrenia before and after antipsychotic drug treatment. There are few case reports showing adverse effects including neuroleptic malignant syndrome, hypoglycemia, hyperglycemia, morning sedation, and heart block [Weighted mean difference in BMI with olanzapine treatment is 0.435 kg/m2 per month (standard deviation of 0.139), whereas, WMD in BMI with the control group is 0.099 kg/m2 per month (SD = 0.002). 2014;47:18.Frank GK, Shott ME, Hagman JO. 2001;10(2):151–7.Powers PS, Santana CA, Bannon YS. L’olanzapine s’est trouvé supérieur en termes de gain de poids et de lutte contre l’obsessionnalité.En revanche, Kazantaris et al n’ont pas trouvé d’intérêt à l’olanzapine par comparaison au placebo chez 15 adolescents AM.Quels facteurs pourraient expliquer ces différences d’efficacité selon les études ou les médicaments ? Neither study participants nor study doctors knew which pills – active or inactive – patients were assigned to receive (A few select members of the staff outside of the research team were aware.). Despite the presence of some contradictory studies, olanzapine treatment has been found beneficial in anorexia nervosa. Australasian Psychiatry. La prise de poids, les obsessions alimentaires et pondérales, l’anxiété et la dépression ont été évaluées. Le but affiché est de « brûler les calories ».La difficulté que l’on rencontre quand on soigne une malade AM est qu’elle dit vouloir essayer de réduire son hyperactivité physique mais qu’elle ne le peut pas. Here, we present a study showing a strong evidence of olanzapine effectiveness in the treatment of AN. 2019;176(6):449–56.Mondraty N, Laird Birmingham C, Touyz S, Sundakov V, Chapman L, Beumont P. Randomized controlled trial of olanzapine in the treatment of cognitions in anorexia nervosa. J Can Acad Child Adolesc Psychiatry. La dose de départ était de 2,5 mg/jour (un demi-comprimé), augmentée jusqu’à 10 mg/j, après accord du malade, en cas d’insuffisance d’efficacité. Salience network and olanzapine in schizophrenia: implications for treatment in anorexia nervosa. 2012;12(21):2324–38.Palaniyappan L, Liddle PF.
Curr Opin Psychiatry.
However, there is a clear need for large scale, more comprehensive studies regarding the efficiency and safety profile of olanzapine treatment in patients with AN in order to have a better understanding of the subject.APA (American Psychiatric Association). Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11C] raclopride. 2007;164(8):1259–65.Milos G, Spindler A, Schnyder U. Am J Psychiatry. Int J Eat Disord. Neural changes associated with appetite information processing in schizophrenic patients after 16 weeks of olanzapine treatment. 2005;58:908–12.Kaye WH, Ebert MH, Raleigh M. Abnormalities in CNS monoamine metabolism in anorexia nervosa. We were also encouraged to find that participants didn’t experience some of the adverse side effects that normally accompany olanzapine use, including elevated cholesterol and blood glucose. Le dossier de 147 malades AM a été étudié : 71 malades ont été exclus pour risque d’intolérance ou refus d’un traitement de ce type.
Reference lists of each study have been further assessed to minimize the risk of overlooking any relevant study.Abstracts of the studies found in the literature search have been analyzed by two authors independently in order to assess their eligibility for literature review.
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