Epub 2019 Oct 15.Pilecky M, Schildberger A, Knabl L, Orth-Höller D, Weber V.BMC Microbiol.
Elsevier Science 2019 Aug 6;19(1):180. doi: 10.1186/s12866-019-1559-7. Epub 2012 Dec 18.Adv Drug Deliv Rev. Please enable it to take advantage of the complete set of features! Springer 2020 Feb;76(2):211-217. doi: 10.1007/s00228-019-02755-5. %PDF-1.7 o Are there any … ����h�[���,���[��3�:ܤʌ��6�p�y�%�~N�~�S�� �rUI}-���m�Y͓�N���< �L4b�ߞ��g�(�b���)������J�h�&��q�G���C搒,�����Jy�74���������sj���R*.AB��]Ƚt�:Dך����,z�7(������X �����9=�����_�=\���z�Ҕ�I_�;�[�X.S&b�c�9n�M��w0��,��f����Y� 2015 Dec;46(6):689-95. doi: 10.1016/j.ijantimicag.2015.09.010. 2016 Jun;38(3):398-401. doi: 10.1097/FTD.0000000000000295.Meng L, Wong T, Huang S, Mui E, Nguyen V, Espinosa G, Desai J, Holubar M, Deresinski S.Pharmacotherapy.
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Epub 2015 Apr 11.van Maarseveen EM, Gipmans S, Vasbinder E, Petjak M, van Zanten AR.Ther Drug Monit. doi: 10.1016/j.ijantimicag.2018.12.014. x��][o9�~���Giצ���Y���x�șxN�H�A�Z�M�V�V2>�j��V�"5�QlS6�햚�E���Ȝ�Z����d/_��*���,��'W�ꏓ��U~�n4�/G�X���\��կ�h��OO���9���Y�#�� �"��$�l�?��/l������g'oKy�����3�"&X"y$5Kt�5�Y@�_�'lz�dS��V�~y������X����z��� ~(�b=4�1�e�ů�x��l�e(�}fV�>�ۣ�|�����g�������##t���`hU�Y0:*�ydOG�@ �s���&�s6�ͼf�E�^bz>��E�N�(�~�F�����q��%|��=0�:�#.���q}��Te\I�3�P(g���H-F7�tp��7!BD\˾>\T���F9��|IW0M>RWQ[|���`�� Manufacturer advises initial doses should be based on body-weight; subsequent dose adjustments should be based on serum-vancomycin concentrations to achieve targeted therapeutic concentrations. 2309 0 obj <>stream Version: 1.2 Effective Date: 26 November 2018 RCCGNR15154 Edmonton Zone Chemistry Page 1 of 2 This document is applicable at site(s): All Sites Bottom line: Use guideline based Vancomycin dosing and monitoring to maximize treatment success and reduce unnecessary plasma Vancomycin levels and needless dosage changes.
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%PDF-1.5 %���� Ukk�c2(Ce���l�X���vT��e�W�r�A�$ŋ�R��\��8h�7�Ao"_oHK,������ Vancomycin Dosing for Adults University Health System Necessary Patient Information for Dosing Actual body weight –the use of actual body weight is recommend for vancomycin dosing CrCl – vancomycin is almost exclusively renally cleared and must be renally adjusted o CrCl = (140-age) x (wt in kg) x 0.85 if female 72 x SCr Type of infection being treated . Epub 2015 Oct 17.J Clin Pharm Ther. <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> IV Vancomycin dosing and monitoring Antibiotic Guidelines Reference Number: 144TD(C)25(H3) Version Number: 6.1 Issue Date: 21/07/2020 Page 1 of 12 It is your responsibility to check on the intranet that this printed copy is the latest version IV Vancomycin dosing and monitoring Antibiotic Guidelines Lead Author: Antibiotic Steering Group Additional author(s) Elizabeth … <>/Metadata 656 0 R/ViewerPreferences 657 0 R>> 2016 Aug;41(4):399-402. doi: 10.1111/jcpt.12399. COVID-19 is an emerging, rapidly evolving situation.
2019 Oct;44(5):639-652. doi: 10.1007/s13318-019-00551-1.Healthcare (Basel). A. �1����W���a�$�&���\�S`>�K"����6.��5874i���������vN|�נ�]�|�[�t\F����x�5���pSk�A��^��bW7g�8$��M3�Cì.pF����=�;D�r��s��n��^����S��� ��(A)T!�?�ki�A���b3E����EE��d?��p��)�0��4M 0��K.$`R�����? The area under the total concentration-time curve (0-24 h) divided by the minimum inhibitory concentration (AUC -Vancomycin trough levels should ideally be drawn immediately before administration of the fourth dose (within 30 minutes of the dose is acceptable), assuming the dose is given at its regular dosing interval (e.g. Given these additional data, it is expected that the updated vancomycin therapeutic drug monitoring guidelines will recommend AUC-based dosing and monitoring. Springer doi: 10.1016/j.ijantimicag.2018.12.014. Mogle BT, Steele JM, Seabury RW, Dang UJ, Kufel WD.Int J Antimicrob Agents.
2018 Dec;52(6):805-810. doi: 10.1016/j.ijantimicag.2018.08.024. Actions may include: pre-emptive dose adjustment, holding dose, checking level, discussion with provider, reassessing the need for vancomycin therapy. Please enable it to take advantage of the complete set of features! Do not restart vancomycin until the random/trough level is estimated or confirmed to be at/near 10-20 mg/dl. ~�F3 the fourth dose of a vancomycin 1g q12h regimen is administered 12 hours after the prior dose).
%%EOF We have evaluated the literature to review optimal dosing and monitoring of intravenous vancomycin in adults, in response to evolving understanding of targets associated with efficacy and toxicity. B.
After more than six decades of its use as the mainstay antibiotic for the treatment of multidrug-resistant Gram-positive bacterial infections, dosing and monitoring of vancomycin therapy have not been optimized. 4 0 obj
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