endobj However, due to the paucity of data, vancomycin dosing for peritonitis in patients on. Please contact Pharm with questions/concerns** Consider adequate loading doses to ensure prompt attainment of steady state drug levels. Doses may vary based on indications, severity, and/or patient factors.
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<> 1 0 obj <> Peritoneal Dialysis (PD)-related Infections Background: ... **Redose vancomycin when levels ~15 mcg/mL (goal is >15 mcg/mL). Do not restart vancomycin until the random/trough level is estimated or confirmed to be at/near 10-20 mg/dl. 3 0 obj <> endobj 2 0 obj 2 0 obj 5 0 obj endobj $����)0r`:��KLJ�l� <> <> 10 0 obj SHC Antimicrobial Dosing Guidelines in Adults on Renal Replacement Therapies **These are general dosing guidelines for reference only. endobj endobj 6 0 obj endobj endobj ���& �8� 3w^�dR3O�Z�ӻ"i��@� 52 automated peritoneal dialysis (APD) is empiric and based on clinical experience rather than evidence. Using Table 5, determine dialysis dosing. endobj
<> 51 peritonitis. l��@]���8�Mf:6�M8F+��]�K4�!��'"ߐ.A ��-H�HhJ��$b�W��|Ar�hw�:w6�[��t�� �m^�@~��E�R�3�l�9LG��>�$�@���D1����i8�E�l�y�h� 4�n��1#�w���(ad��Z2{ o Routine prophylaxis for patients on continuous ambulatory peritoneal dialysis or hemodialysis o Treatment (chosen for dosing convenience) of infections caused by beta-lactam-sensitive gram-positive microorganisms in patients who have renal failure o Use of vancomycin solution for topical application or irrigation. -If trough levels are >35 mg/L, hold vancomycin, check a vancomycin level and SCr q12h, and restart with a new vancomycin regimen when the level is within the therapeutic range. 1 0 obj <>
Guidelines by an ad hoc European committee on the assessment of growth and nutritional status in children on Chronic Peritoneal Dialysis Consensus guidelines for the treatment of Peritonitis in pediatric patients receiving Peritoneal Dialysis (2000) EPS.
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The UCSF Adult Vancomycin Dosing Calculator (Excel file for download) can also be used to develop revised dosing regimens based on vancomycin levels obtained. 3. endobj endobj Initial Treatment of peritoneal dialysis peritonitis in patients carrying out CAPD: The PD nursing team will ideally obtain results of cell count and Gram stain before initiating treatment. endobj 4 0 obj %PDF-1.3 8 0 obj %����
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Actions may include: preemptive dose adjustment, holding dose, checking leve- l, discussion with provider, reassessing the need for vancomycin therapy. �1����W���a�$�&���\�S`>�K"����6.��5874i���������vN|�נ�]�|�[�t\F����x�5���pSk�A��^��bW7g�8$��M3�Cì.pF����=�;D�r��s��n��^����S��� ��(A)T!�?�ki�A���b3E����EE��d?��p��)�0��4M 0��K.$`R�����? <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Using Table 2, determine target pre-vancomycin level based on clinical indication. ~�F3 Allow sufficient time for drug clearance before restarting next dose. ��獞��-X�Є endobj stream Gentamicin Vancomycin Vancomycin No organisms seen Gram +ve Gram -ve PD fluid result 2.6. Single pre-dialysis level (preferred) Alternative: single level 4 hours after completion of dialysis session CRRT‡ Initial: 20-25 mg/kg x 1 (max 2gm) Maintenance: 10 – 15 mg/kg Q24H N/A Q24H: Peak 1hr after 2nd or 3rd dose; Trough 30 min before 3rd or 4th dose, respectively Peritoneal dialysis 10 – 15 mg/kg IV x1, then dose by level N/A %���� Using Tables 3 or 4, identify initial dosing interval according to target pre-vancomycin level, age, and serum creatinine.
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B. 11 0 obj [278 333 0 0 0 0 0 0 333 333 0 0 278 333 278 278 556 556 556 0 556 556 0 0 0 0 333 333 0 584 584 0 0 722 722 722 722 667 611 778 722 278 556 722 611 833 722 778 667 0 722 667 611 722 667 944 0 667 0 0 0 0 0 0 0 556 611 556 611 556 333 611 611 278 278 556 278 889 611 611 611 611 389 556 333 611 556 778 556 556 500] serum creatinine is above normal, renal function is changing 4. 9 0 obj <> <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI]>>/MediaBox[0 0 612 792]/Contents 41 0 R/Group<>/Tabs/S/ArtBox[0 0 612 792]/CropBox[0 0 612 792]/Parent 110 0 R>> u�Dm(ɧ 3��b���Q���70�P�����>�p�r������G�����[��6��6� <> 50 Intraperitoneal vancomycin is the first line therapy in the management of peritoneal dialysis-related. [10 0 R] 7 0 obj
Typical dose = 2,000 mg, Maximum = ... For antibiotics not listed in the above table, refer to the Renal Dosing Protocol … 750 mg QHD Pre-HD level: 15-20
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